细胞因子受体的heterodimeric IL-23由IL-12Rbeta1和一种新型细胞因子受体亚基,IL-23R。
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Parham C, Chirica M, Timans J, Vaisberg E,特拉维斯M,张J, Pflanz年代,张R,辛格KP,织女星F, W,瓦格纳J,奥法雷尔,麦克拉纳罕T, Zurawski年代,所有C,戈尔曼D, Rennick DM, Kastelein RA, de Waal Malefyt R,摩尔千瓦
细胞因子受体的heterodimeric IL-23由IL-12Rbeta1和一种新型细胞因子受体亚基,IL-23R。
2002年J Immunol。168年6月1;(11):5699 - 708。
- PubMed ID
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12023369 (在PubMed]
- 文摘
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IL-23是heterodimeric细胞因子由IL-12p40可溶性受体亚单位和小说cytokine-like IL-12p35相关单元,称为p19。人类和小鼠IL-23白介素展览一些活动类似,但有不同的能力来刺激特定的记忆T细胞的数量。如白介素,IL-23 IL-12R单元IL-12Rbeta1绑定。然而,它不使用IL-12Rbeta2。在这项研究中,我们确定一个新的hemopoietin受体家族的成员作为IL-23受体的亚基,“IL-23R。”IL-23R pairs with IL-12Rbeta1 to confer IL-23 responsiveness on cells expressing both subunits. Human IL-23, but not IL-12, exhibits detectable affinity for human IL-23R. Anti-IL-12Rbeta1 and anti-IL-23R Abs block IL-23 responses of an NK cell line and Ba/F3 cells expressing the two receptor chains. IL-23 activates the same Jak-stat signaling molecules as IL-12: Jak2, Tyk2, and stat1, -3, -4, and -5, but stat4 activation is substantially weaker and different DNA-binding stat complexes form in response to IL-23 compared with IL-12. IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. The ability of cells to respond to IL-23 or IL-12 correlates with expression of IL-23R or IL-12Rbeta2, respectively. The human IL-23R gene is on human chromosome 1 within 150 kb of IL-12Rbeta2.