类维生素a——皮肤的迹象在不久的将来将会受益?
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Zouboulis CC
类维生素a——皮肤的迹象在不久的将来将会受益?
皮肤:皮肤杂志杂志》2001;9月- 10月14(5):303 - 15所示。
- PubMed ID
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11586072 (在PubMed]
- 文摘
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类化合物与多效性的函数和相对选择性的针对某些皮肤结构。维生素,因为视黄醇(维生素A)在体内不能合成,必须来源于饮食,但也与intracrine荷尔蒙活动,因为视黄醇转化为分子核受体结合,展示他们的活动,并被灭活。类维生素a对靶细胞施加其影响绑定和激活核类维生素a受体。类维生素a受体结合的配体形成的二聚体。可以形成之间形成两个不同的类维生素a受体分子,而且X受体类维生素a和维生素D受体之间以及triiodothyronin受体。这一事实表明复杂类维生素a和进一步的激素信号转导分子之间的相互作用。交互类维生素a受体与其他转录因子激活信号转导机制,例如AP-1,可能提供类维生素a的离解效应。类维生素a展览竞赛的活动也可以中性拮抗剂和逆受体激动剂。外用和口服视黄醇、维甲酸异维甲酸,bexarotene,局部alitretinoin,视黄醛,motretinide, adapalene, tazarotene,与其他人acitretin组成的列表类维生素a。牛皮癣和相关疾病,先天性疾病的角质化,痤疮,光老化和维生素缺乏一个古典批准类维生素A治疗的适应症,而皮肤t细胞淋巴瘤,AIDS-associated卡波西氏肉瘤,急性早幼粒细胞白血病,目前光化性雀斑被证实。 In addition, retinoids have been successfully used in several other dermatoses, e.g. epithelial precanceroses and tumors, seborrhea, rosacea and acneiform dermatoses, lichen planus, eosinophilic folliculitis, condylomata accuminata, lichen sclerosus and atrophicus. Highly receptor selective molecules, retinoic acid receptor-beta-inducers, AP-1 complex antagonists, and inverse agonists will be probably lead the retinoid development in the near future. New, more effective and less toxic retinoids, alone or in combination with other drugs and new delivery systems may provide therapeutic solutions for benign and malignant proliferative skin diseases, such as psoriasis and non-melanoma tumors, cancer chemoprevention and differentiation therapy.