Tamsulosin:回顾其药理学和治疗效果的管理下尿路症状。

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邓恩CJ,马西森,Faulds DM

Tamsulosin:回顾其药理学和治疗效果的管理下尿路症状。

衰老药物。2002;19 (2):135 - 61。

PubMed ID

11950378 (在PubMed

]

文摘

Tamsulosin subtype-selectiveα(1)-和α肾上腺素受体拮抗剂(1 d)。α(1)受体主要从事前列腺、前列腺囊,前列腺尿道和膀胱、前列腺和膀胱平滑肌的松弛与改进最大尿流(Q (max))和下尿路症状的减轻(附近地区)在良性前列腺增生(BPH)患者。Tamsulosin 0.4毫克,每日一次,在一个modified-release配方增加Q (max)和症状评分改善相对于基线比安慰剂更大程度上在12 - 13周的双盲,随机,多中心,在附近地区患者临床试验,治疗Q之间的统计学意义(max)值在两三个美国和欧洲的研究发表。Tamsulosin轻微到严重患者是有效的附近地区与良性前列腺增生有关,在糖尿病患者和老年人,并且不干扰共存的降压治疗。集中数据基于病人接受tamsulosin 0.4或0。8毫克,每日一次,表明功效长达6年的维护。Tamsulosin 0.4毫克,每日一次,是类似的功效alfuzosin 2.5毫克,每日3次,用更少的倾向于引起低血压的作用,在一个双盲,随机12周试验。效益的药物也被显示在急性尿潴留或慢性非细菌性的前列腺炎患者,那些接受高能经尿道微波热疗,与辐射诱导尿道炎和前列腺癌患者。眩晕和射精异常声明是最常见的不良事件,衰弱,体位低血压和心悸被较少(1)发生率2%,患者接受tamsulosin 0.4毫克,每日一次。Tamsulosin尚未与临床相关的重大变化在血压的临床试验。 CONCLUSION: The alpha(1A)- and alpha(1D)-adrenoceptor antagonist tamsulosin, given at a dosage of 0.4 mg once daily in a modified-release formulation, is effective and well tolerated in the treatment of LUTS associated with BPH. Although the drug has been directly compared to date with one other agent only, data show overall that tamsulosin clearly offers advantages over other alpha(1)-adrenoceptor antagonists in terms of the need for a single daily dose only, and its low potential for hypotensive effects or interference with concomitant antihypertensive therapy. Dosage titration at the start of treatment is not necessary. Tamsulosin has a rapid onset of action and is effective in patients with moderate or severe symptoms. The drug is therefore a valuable therapeutic option, with both demonstrated and potential advantages over older nonselective agents, in the management of patients with LUTS associated with BPH.

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药物

Tamsulosin