Follitropinα在不孕症:审查。

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果阿KL,瓦格斯塔夫AJ

Follitropinα在不孕症:审查。

BioDrugs。1998年3月,9 (3):235 - 60。

PubMed ID
18020563 (在PubMed
]
文摘

Follitropinα(重组人促卵泡激素;follitropin阿尔法)是一种重组卵泡刺激素(FSH)、内源性促性腺激素。与FSH的产品来源于尿液(尿促性素(人绝经期促性腺激素),urofollitropin和高纯度urofollitropin], follitropinα是容易获得并显示批次一致性。,它是免费的luteinising激素(LH)活动和污染物尿蛋白,可以自行皮下注射。在女性接受体外受精胚胎移植(IVF-ET) follitropinα似乎刺激卵泡发展效应大于urine-derived FSH产品作为一个整体。在直接比较类似的效果urofollitropin但是产生更多的卵母细胞刺激周期比高纯度urofollitropin和尿促性素。1个小试验初步结果表明类似的功效follitropinα和βfollitropin。怀孕、活产和多胞胎在所有治疗组相似。在女性排卵诱导clomifene-resistant组II停止排卵,follitropinα生产的排卵率、卵泡发育和怀孕像urofollitropin或高纯度urofollitropin所看到的。长期低剂量的follitropinα与较低的毛囊数量和趋势与传统相比更少的多胞胎follitropinα或urofollitropin方案。 Data from women with WHO group I anovulation and from infertile men are scant. Tolerability has not differed between follitropin alpha and other FSH products. The incidence of general events (e.g. headache, nausea, ovarian cyst), local irritations at injection site and ovarian hyperstimulation syndrome resembled those for comparator FSH products. However, it appears that follitropin alpha can be tolerated in instances of severe allergic reaction to urine-derived products. CONCLUSIONS: In women undergoing IVF-ET, follitropin alpha appears to have a greater stimulatory effect on follicle development than urine-derived FSH products as a group and is at least as well tolerated as these preparations; preliminary data indicate similar efficacy to follitropin beta. At present, its efficacy in women with WHO group II anovulation disorder has been shown to be similar to that of the older products. Compared with urinary FSH products, the benefits of follitropin alpha lie in its reliable supply, consistency of production, lack of contaminant urinary proteins and ease of self-administration. Given these practical advantages, and the apparently greater effect on follicular development overall in women undergoing IVF-ET, recombinant products such as follitropin alpha are expected to eventually replace older urine-derived FSH preparations and claim a prominent position in the treatment of infertility.

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药物
药物靶点
药物 目标 类 生物 药理作用 行动
Follitropin 促卵泡激素受体 蛋白质 人类
是的
受体激动剂
 细节