多药耐药性种代号为ABCB1的腺苷triphosphate-binding盒式B1 () (1) G2677T /基因多态性与肺癌的高风险有关。
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加西亚Gervasini G, Carrillo是的,M,圣何塞C, Cabanillas,贝尼特斯J
多药耐药性种代号为ABCB1的腺苷triphosphate-binding盒式B1 () (1) G2677T /基因多态性与肺癌的高风险有关。
癌症。2006年12月15日,107 (12):2850 - 7。
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17120199 (在PubMed]
- 文摘
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背景:22 (P-gp)是一个跨膜转运蛋白编码的腺苷triphosphate-binding盒式B1种代号为ABCB1的()多药耐药性(1)基因,在细胞抵御环境中扮演重要角色的攻击,就像那些由外源性物质生成的。在肺P-gp表示,有人建议运输这些化合物的间质内腔。方法:两种代号为ABCB1的功能多态性进行检测时,发现G2677T /(21外显子)和C3435T(外显子26)在肺癌患者和对照组。结果:而3435 t等位基因和基因型频率没有改变两国学习小组,肺癌患者显示更高频率的2677 t等位基因变体与对照组(0.67和0.43;P <措施;优势比[或],2.6;95%置信区间(95%置信区间),1.7 - -4.0)。肿瘤的组织学类型,包括在这项研究中,鳞状细胞癌最强烈有关2677 t等位基因的存在(OR, 3.92;95%可信区间,2.2 - -6.9),特别是与2677 TT基因型(OR, 6.75;95%可信区间,3.0 - -15.2)。 In a haplotype analysis, homozygous wild-type alleles were classified as genotype A, heterozygous alleles were classified as genotype B, and homozygous mutant allele were classified as genotype C both in exon 21 (first letter) and in exon 26 (second letter) loci. The haplotype CB displayed the highest association with lung cancer (OR, 18.09; 95% CI, 2.4-139.2). CONCLUSIONS: The current results taken together suggest that, aside from other known causes of lung cancer, such as tobacco smoke, the existence of polymorphisms in the ABCB1 gene and, specifically, the presence of the G2677T mutation can be crucial in conferring susceptibility to lung cancer. Further studies comprising larger populations are needed to confirm these preliminary findings.