前列腺干细胞抗原(PSCA)表达增加格里森评分高,晚期前列腺癌骨转移。
文章的细节
-
引用
复制到剪贴板 -
顾Z,托马斯·G Yamashiro J, Shintaku IP, Dorey F, Raitano,威特,Loda M, Reiter再保险JW说
前列腺干细胞抗原(PSCA)表达增加格里森评分高,晚期前列腺癌骨转移。
致癌基因。2000年3月2;19 (10):1288 - 96。
- PubMed ID
-
10713670 (在PubMed]
- 文摘
-
最近前列腺干细胞抗原(PSCA)是一个定义的同系物Thy-1 / Ly-6 glycosylphosphatidylinositol家族(GPI)固定细胞表面抗原。PSCA mRNA表达基底细胞的正常前列腺癌和前列腺癌的80%以上。本研究的目的是检查PSCA蛋白表达在人类前列腺癌的临床标本。提出了五个单克隆抗体对PSCA-GST融合蛋白和筛选的能力识别PSCA在细胞表面的人类前列腺癌细胞。免疫组织化学分析PSCA表达式进行石蜡包埋部分25正常组织,112年主要前列腺癌和九前列腺癌骨转移。PSCA前列腺肿瘤组织的表达水平的量化并与表达在邻近正常腺体。抗体检测PSCA表达在细胞表面的正常和恶性前列腺细胞和区分三个细胞外PSCA的抗原表位。前列腺癌和变移上皮与PSCA反应强烈。PSCA染色也在胎盘滋养层,肾收集管和神经内分泌细胞在胃和结肠。所有其他正常组织测试呈阴性。 PSCA protein expression was identified in 105/112 (94%) primary prostate tumors and 9/9 (100%) bone metastases. The level of PSCA expression increased with higher Gleason score (P=0.016), higher tumor stage (P=0.010) and progression to androgen-independence (P=0. 021). Intense, homogeneous staining was seen in all nine bone metastases. PSCA is a cell surface protein with limited expression in extraprostatic normal tissues. PSCA expression correlates with tumor stage, grade and androgen independence and may have prognostic utility. Because expression on the surface of prostate cancer cells increases with tumor progression, PSCA may be a useful molecular target in advanced prostate cancer.