人类UGT1基因复合体位点编码13个UDPglucuronosyltransferase基因。

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Gong QH, Cho JW, Huang T, Potter C, Gholami N, Basu NK, Kubota S, Carvalho S, Pennington MW, Owens IS, Popescu NC

人类UGT1基因复合体位点编码13个UDPglucuronosyltransferase基因。

药物遗传学。2001;11(4):357-68。

PubMed ID

11434514 (PubMed视图

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摘要

最初的新型UGT1复合体位点先前显示编码6种不同的udp -葡萄糖醛基转移酶(转移酶)基因，现已扩展并证明可指定总共13种同种异构体。这些基因被命名为UGT1A1到UGT1A13p，还有4个伪基因。UGT1A2p和UGT1A11p到UGT1A13p要么有核苷酸缺失，要么有缺陷的TATA盒子，因此是假的。在基因座的5'区，13个独特的外显子1以串联阵列排列，每个外显子都有自己的近端TATA盒元件，并且依次与四个共同外显子相连，从而允许独立的转录起始产生重叠的初级转录本。预计在9个可存活的初级转录本中，只有前导外显子与4个共同外显子进行剪接，产生具有相同3'端的mrna和具有相同羧基端的转移酶同工酶。独特的氨基末端指定了受体-底物的选择，而共同的羧基末端显然指定了与共同的供体底物udp -葡萄糖醛酸的相互作用。在扩展区域，可行的TATA盒子是A(A)TgA(AA)T或AT14AT;在原始基因座中，UGT1A1的元件为A(TA)7A，其他所有基因的元件为TAATT/CAA(A)。UGT1A1指定至关重要的胆红素转移酶异构体。外显子1的相互关系如下:UGT1A2p ~ UGT1A5组成一个相同度为87 ~ 92%的cluster a, UGT1A7 ~ UGT1A13p组成一个相同度为67 ~ 91%的cluster B。 For the two not included in a cluster, UGT1A1 is more identical to cluster A at 60-63%, whereas UGT1A6 is identical by between 48% and 56% to all other unique exons. The locus was expanded from 95 kb to 218 kb. Extensive probing of clones beyond 218 kb with coding nucleotides for a highly conserved amino acid sequence present in all transferases was unable to detect other exons 1. The mRNAs are differentially expressed in hepatic and extrahepatic tissues. This locus is indeed novel, indicating the least usage of exon sequences in specifying different transferase isozymes that have an expansive substrate range.

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名字	UniProt ID
UDP-glucuronosyltransferase 1 - 9	O60656	细节
UDP-glucuronosyltransferase 1 - 1	P22309	细节
UDP-glucuronosyltransferase 1 - 4	P22310	细节
UDP-glucuronosyltransferase 1 - 3	P35503	细节
UDP-glucuronosyltransferase 1 - 10	Q9HAW8	细节
UDP-glucuronosyltransferase 1 - 8	Q9HAW9	细节
UDP-glucuronosyltransferase 1 - 6	P19224	细节
UDP-glucuronosyltransferase 1 - 7	Q9HAW7	细节