三个小说在UGT1A10单核苷酸多态性。
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火箭M,小泽年代,齐藤Y, Jinno H, H T, Nokihara H,岛田Y、Kunitoh H,山本N,咸宁Y,山田Y, Shirao K, Muto M, Mera K, Goto K, Ohmatsu H,日本久保田公司K, Niho年代,Kakinuma R,南城H, Ohtsu,吉田T, Saijo N,泽田师傅J
三个小说在UGT1A10单核苷酸多态性。
药物金属底座Pharmacokinet。2002; 17 (5): 488 - 90。
- PubMed ID
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15618702 (在PubMed]
- 文摘
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三个新颖的单核苷酸多态性(snp)被发现在UDP-glucuronosyltransferase (UGT) 1 a10基因24日本各种癌症患者服用抗肿瘤药物,伊立替康(CPT-11)。单核苷酸多态性检测如下:1)SNP, MPJ6_U1A003;基因名称、UGT1A10;加入数量,AF297093;长度,25基地;5‘-CAGATGCCATGAC / TTTTCAAGGAGAG-3’。2)单核苷酸多态性,MPJ6_U1A004;基因名称、UGT1A10;加入数量,AF297093;长度,25基地; 5'-CCTAGAAATAGCC/TTCTGAAATTCTC-3'. 3) SNP, MPJ6_U1A030; GENE NAME, UGT1A10; ACCESSION NUMBER, AF297093; LENGTH, 25 bases; 5'-GGTTGTAGTCATG/ACCAGAGGTGAGT-3' All the three SNPs were located in exon 1 and their frequencies were all 0.021. Among these SNPs, MPJ6_U1A003 and U1A030 resulted in amino acid alterations, T202I and M59I, respectively. The third SNP, MPJ6_U1A004, introduced a synonymous amino acid change (A231A).