等离子体tetranectin水平和类风湿性关节炎患者的疾病活动。

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坎普EF、Kopeikina LT Koutsoukos V,斯塔夫里蒂斯J

等离子体tetranectin水平和类风湿性关节炎患者的疾病活动。

J Rheumatol。1997年2月,24 (2):262 - 8。

PubMed ID

9034981 (在PubMed

]

文摘

目的:我们研究了改变等离子体tetranectin的水平,一个新的监管机构的纤溶酶原激活物,在类风湿性关节炎(RA)患者与疾病活动和其他纤溶变量。方法:Tetranectin (TN),组织类型纤溶酶原激活物(t-PA)和纤溶酶原激活物抑制剂(PAI-1)定量评估(ELISA)等离子体的41 RA患者和30名健康受试者,α2-Antiplasmin amidolytic活动评估的方法。疾病活动确定综合斯托克指数,衡量在RA炎症过程。患者分为3组根据斯托克指数得分的疾病活动:minimal-mild, 1 - 7: b .温和。8 - 11:c .严重。12 - 17。结果:等离子TN患者明显低于健康受试者的(9.11 mg / l (4.97 - -13.49), 12.05 (9.50 - -13.60) mg / l,中值(范围),分别;p = 0.0001)。TN减少的疾病活动的增加。TN和斯托克指数之间显著负相关。 C-reactive protein and erythrocyte sedimentation rate was found (rs = -0.49, p = 0.0012; rs = -0.44, p = 0.0044; rs = -0.37, p = 0.016, respectively). alpha 2-Antiplasmin activity was elevated in patients compared to healthy subjects [105.0% (53.0-146.0), 70.6% (48.2-124.0), median (range), respectively; p = 0.0001], showing a negative correlation with Stoke Index (rs = -0.38, p = 0.0139). The close positive correlation of TN with alpha 2-antiplasmin (rs = 0.66, p = 0.0001) and the absence of correlation with t-PA and PAI-1 were explained by the involvement of TN and alpha 2-antiplasmin in localized rather than in systemic fibrinolysis. CONCLUSION: Our findings suggest TN plays a role in the pathophysiology of RA and point to the usefulness of TN assessment as a specific fibrinolytic marker in the evaluation of disease activity in patients with RA. The role of TN in the intraarticular regulation of fibrinolysis, important for the expansion of pannus, tissue remodeling and angiogenesis, is discussed.

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药物靶点

药物	目标	类	生物	药理作用	行动
Tenecteplase	Tetranectin	蛋白质	人类	未知的	不可用	细节