5-azacytidine在真核生物的生物效应。

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5-azacytidine在真核生物的生物效应。

肿瘤。1974;30(5):405 - 22所示。

PubMed ID

4142650 (在PubMed

]

文摘

5-Azacytidine (nsc - 102 816)准备综合、独立隔绝的文化滤液轮枝链霉菌ladakanus。这是一个s-triazine模拟的胞嘧啶核苷具有广泛的生物效应。在哺乳动物tissueit磷酸化5-azacytidine 5-phosphates纳入不同种类的rna和DNA。5-Azacytidine 5-monophosphate抑制orotidine 5-phosphate脱羧酶阻断嘧啶的从头合成。5-azacytidine政府后迅速分解肝脏多核糖体被观察到;此外,在不同的系统产生深远的抑制作用的药物的成熟核糖体RNA被发现。5-Azacytidine干扰不同的诱导肝酶;在某些情况下,他们的活动是提高自酶降解率却降低了。药物的抑制细胞生长的影响主要是对淋巴白血病虽然最近的一些报告显示其行动也对人类的实体肿瘤。化疗同时5-azacytidine结果白血病小鼠的肝脏和脾脏的抑郁合成聚胺类。 5-Azacytidine exhibits furthermutagenic, abortive, immunosuppressive, antimitotic, radioprotective and virostatic effects. The drug also affects DNA and protein synthesis in embryonic tissues, cells intissue culture, regenerating livers, in bacteria and phages. The changes associated with the emergence of resistance towards 5-azacytidine are associated with the decreased activity of uridine kinase in mouse leukemia cells. On the contrary, in adult rate livers5-azacytidine administration leads to the increased activity of this enzyme. Differentauthors have used 5-azacytidine as a tool for the study of biochemical mechanisms connected with a cell proliferation and division.

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药物

阿扎胞苷