Rizatriptan:一个更新的使用管理的偏头痛。

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惠灵顿K, Plosker GL

Rizatriptan:一个更新的使用管理的偏头痛。

药。2002;62 (10):1539 - 74。

PubMed ID

12093318 (在PubMed

]

文摘

Rizatriptan口头是一个活跃的血清素5 -(1)受体激动剂有说服力地和选择性地结合5 - (1 b / 1 d)亚型。早期的临床试验表明,rizatriptan 5或10毫克比安慰剂更有效提供缓解疼痛和无痛状态,缓解偏头痛的症状相关,恢复正常功能的能力和改善病人的生活质量,并表明rizatriptan提供更快的摆脱痛苦和减少恶心比口服舒马曲坦在更大程度上。最近,rizatriptan 10毫克被证明是更有效的比佐米曲坦2.5毫克或naratriptan 2.5毫克postdose产生无痛状态2小时。此外,与naratriptan相比,更多的患者接受rizatriptan疼痛从1小时开始免费或有缓解疼痛。患者的数量在2小时后明显高于正常功能的能力比naratriptan或佐米曲坦rizatriptan。Rizatriptan也通常比佐米曲坦或naratriptan更有效缓解migraine-associated症状。Rizatriptan一般耐受性良好,不良事件通常轻度和短暂的。最常见的不良事件与最近随机试验rizatriptan衰弱/疲劳、头晕、嗜睡和恶心。有一个趋势的不良事件发生率较低与rizatriptan与佐米曲坦相比(38.8% vs 31.2)。然而,rizatriptan相关的不良事件发生率显著高于naratriptan (39 vs 29%)。 The incidence of chest pain was similar after the administration of rizatriptan, zolmitriptan or naratriptan (2 to 4%). CONCLUSION: Rizatriptan is an effective drug for the acute treatment of moderate or severe migraine. Oral rizatriptan 5 and 10mg have shown greater efficacy than placebo in providing pain relief, an absence of pain, relief from associated symptoms, normal functional ability and an improvement in patient quality of life. Earlier results showed that rizatriptan provides faster freedom from pain and reduces nausea to a greater extent than oral sumatriptan. More recent studies have shown that rizatriptan 10mg provides faster pain relief and a higher percentage of patients with an absence of pain and normal functional ability at 2 hours than naratriptan 2.5mg or zolmitriptan 2.5mg. The efficacy of rizatriptan is retained when used in the long term and the drug is generally well tolerated. Although well designed studies comparing rizatriptan with almotriptan, eletriptan and frovatriptan would further define the position of rizatriptan, current data suggest rizatriptan should be considered as a first-line treatment option in the management of migraine.

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药物

Rizatriptan

药物靶点

药物	目标	类	生物	药理作用	行动
Rizatriptan	5 -羟色胺受体1 b	蛋白质	人类	是的	受体激动剂	细节
Rizatriptan	5 -羟色胺受体1 d	蛋白质	人类	是的	受体激动剂	细节