溃疡性角膜炎perifosine患者胃肠道间质肿瘤。

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Shome D,特伦特J, Espandar L, Hatef E, Araujo DM,歌曲CD, Kim SK Esmaeli B

溃疡性角膜炎perifosine患者胃肠道间质肿瘤。

眼科学。2008年3月,115 (3):483 - 7。doi: 10.1016 / j.ophtha.2007.11.016。Epub 2008年1月16日。

PubMed ID

18201764 (在PubMed

]

文摘

用途:Perifosine小说alkylphospholipid具有抗增殖特性归因于抑制蛋白激酶B。作者描述一种溃疡性角膜炎5晚期胃肠道间质瘤患者(要点)参加的I / II期试验perifosine结合伊马替尼。设计:病例系列。参与者:五个病人(1人,4女)imatinib-resistant转移依据接受伊马替尼和perifosine口服药。方法:并回顾医疗记录。主要结果测量:眼部与perifosine相关的毒性和溃疡性角膜炎。结果:眼部症状包括发红、疼痛、流泪,畏光和视力逐渐下降。裂隙灯活组织镜检查在每种情况下显示外围,paralimbal,环形,肤浅的角膜基质渗透和溃疡性角膜炎,想起了自身免疫性疾病如风湿性关节炎角膜炎。溃疡性角膜炎单方面在3和两国在2例;这是国家癌症研究所二级(症状干扰函数但不干扰日常生活活动)在所有的病人。 All 5 patients had imatinib-resistant metastatic GIST and had continued on the highest dose of imatinib tolerated and initiated therapy with perifosine 100 mg daily or 900 mg weekly. A combination of topical steroids, topical antibiotics, and lubricating drops were used to manage ulcerative keratitis. In the first 3 patients, ulcerative keratitis initially was treated with topical antibiotics without improvement, but subsequently they improved significantly after topical steroids were added. CONCLUSIONS: A vision-threatening form of ulcerative keratitis may occur in patients taking perifosine. It is possible that imatinib in combination with perifosine contributes to this corneal toxicity; however, the authors are unaware of this ocular toxicity having been reported for imatinib when used without perifosine. The visual loss associated with perifosine may be reversible if detected and treated early and with judicious early use of topical steroids, topical antibiotic coverage, and lubrication.

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药物靶点

药物	目标	类	生物	药理作用	行动
Perifosine	RAC-alpha丝氨酸/ threonine-protein激酶	蛋白质	人类	未知的	不可用	细节