影响抗抑郁/应急药物苯乙肼在老鼠大脑丙氨酸和丙氨酸氨基转移酶。
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黄塔VA、家长MB, JT, Paslawski T,马丁•伊尔贝克GB
影响抗抑郁/应急药物苯乙肼在老鼠大脑丙氨酸和丙氨酸氨基转移酶。
细胞摩尔一般人。2001年8月,21 (4):325 - 39。
- PubMed ID
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11775064 (在PubMed]
- 文摘
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1。苯乙肼(请)是一种抗抑郁和抗焦虑的性质。急性和慢性请政府增加大脑GABA水平产生影响,至少在某种程度上,一个GABA代谢酶的活性,抑制GABA转氨酶(GABA-T)。2。之前的初步报告表明,急性请治疗也提升大脑丙氨酸的水平。与GABA,丙氨酸的代谢包括吡哆醛phosphate-dependent转氨酶。3所示。在这里的研究报告,严重的影响请治疗各种氨基酸的含量,其中一些也代谢吡哆醛phosphate-dependent转氨酶在鼠全脑相比。6个氨基酸的调查,只有伽马氨基丁酸和丙氨酸含量升高(以时间和剂量依赖性的方式)。4所示。 The elevation in brain alanine levels could be explained, at least in part, by a time- and dose-dependent inhibitory effect of PLZ on alanine transaminase (ALA-T), although as with GABA the increases are higher than expected from the degree of enzyme inhibition produced. In addition, we also showed that the elevation in alanine levels and the inhibition of alanine transaminase in the brain are retained after 14 days of PLZ treatment, and that PLZ produces a marked increase in extracellular levels of alanine. 5. These results are discussed in terms of their relevance to synaptic function and to the pharmacological profile of PLZ.