诺氟沙星、氟喹诺酮类抗菌剂。分类、作用机理和体外活性。

文章的细节

引用

复制到剪贴板

戈尔茨坦EJ

诺氟沙星、氟喹诺酮类抗菌剂。分类、作用机理和体外活性。

地中海J。1987年6月26日,82 (6):3 - 17。

PubMed ID

3111257 (在PubMed

]

文摘

诺氟沙星是一种口服吸收与一个氟氟喹诺酮类抗菌位置6和哌嗪环位置7。这些变化导致显著增强(与之相比,年长的喹诺酮类)的体外抗菌活性。具体来说,诺氟沙星包括铜绿假单胞菌的抗菌谱,以及肠道病原体。诺氟沙星也活跃penicillin-susceptible和抗淋病奈瑟氏菌菌株。相对于其活动对革兰氏阴性细菌,对革兰氏阳性球菌诺氟沙星有点不那么活跃。一般来说,葡萄球菌更容易受到毒品比是链球菌。如同所有的氟喹诺酮类原料药,诺氟沙星对厌氧细菌的活动很差。尿路细菌分离,提出了以下Bauer-Kirby磁盘扩散zone-size断点:大于或等于17毫米,敏感;13 - 16毫米,中间;小于或等于12毫米,耐药。 Bacteria with minimal inhibitory concentrations (MICs) less than or equal to 16 micrograms/ml are considered susceptible; those with MICs greater than or equal to 32 micrograms/ml are considered resistant to norfloxacin. The mechanism of action of norfloxacin involves inhibition of the A subunit of the important bacterial enzyme DNA gyrase, which is essential for DNA replication. Plasmid-mediated resistance to the fluoroquinolones is not encountered. Further, although some cross-resistance within the fluoroquinolone class has occurred, there is little cross-resistance between norfloxacin and antibiotics of other classes.

beplay体育安全吗DrugBank数据引用了这篇文章

药物

诺氟沙星