临床相关性antibiotic-induced内毒素释放在接受肝切除的患者。

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石川M, Miyauchi T,八木K, Chikaishi H, Fukuta Y,宅一生H,原田M,年代友吉达常常结伴,田代年代

临床相关性antibiotic-induced内毒素释放在接受肝切除的患者。

1999年世界J Surg. Jan; 23 (1): 75 - 9。

PubMed ID

9841767 (在PubMed

]

文摘

已经证明,抗生素结合penicillin-binding蛋白3 (PBP3)相关的比那些更大的释放内毒素结合PBP2在体外和动物模型。本研究的目的是评估的潜在临床意义antibiotic-induced内毒素肝切除术后释放。45病人肝切除在我们诊所登记。患者分为两组。A组(n = 26):抗生素结合主要PBP3,包括头孢美唑(CMZ) latamoxef (LMOX) flomoxef (FMOX)。B组(n = 19);绑定到PBP2和PBP3抗生素,包括头孢唑啉(CEZ)、头孢哌酮(CPZ) cefotiam (CTM)。术后并发症、肝脏功能测试和化学介质(内毒素,白细胞介素(il - 6,引发),肿瘤坏死因子α(TNFalpha)、粒细胞集落刺激因子(g - csf) hepatotrophic生长因子(HGF)在肝切除术后检查。没有明显差异的背景中两组。8每组患者出现术后并发症; in particular, 9 of 13 patients with biliary tract carcinoma developed postoperative complications. No significant elevation of peripheral blood endotoxin was noted by the endospecy method, in any of the patients, although six died following sepsis. Pre- and postoperative levels of cytokines showed no significant difference between the two groups. Our data suggest that clinical antibiotic-induced endotoxin release would not occur after hepatic resection regardless of the antibiotic, probably owing to continuous scavenging of endotoxin from peripheral blood.

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药物靶点

药物	目标	类	生物	药理作用	行动
Latamoxef	Penicillin-binding蛋白3	蛋白质	枯草芽孢杆菌(168株)	是的	抑制剂	细节