Methylenetetrahydrofolate还原酶基因型、维生素B12和叶酸影响血液透析患者血浆同型半胱氨酸。

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中村T,西园寺K, Hiejima Y, Hirayama H, Tago K, Takano H,在M, Hayashi K,川端康成M, Funamizu M, Makita Y,要么

Methylenetetrahydrofolate还原酶基因型、维生素B12和叶酸影响血液透析患者血浆同型半胱氨酸。

肾脏J说。2002年5月,39 (5):1032 - 9。

PubMed ID

11979347 (在PubMed

]

文摘

半胱氨酸,一个公认的心血管风险因素,在血液透析(HD)患者频繁。5共同多态性,10-methylenetetrahydrofolate还原酶(MTHFR)基因C - - > T替换在677核苷酸,与同型半胱氨酸(Hcy)水平高度相关。我们调查了三个因素是否参与蛋氨酸的周期可能会影响HD患者的血浆Hcy浓度:MTHFR多态性;维生素B12,必不可少的辅助因子;和叶酸,底物。在横断面研究中,血清维生素B12、叶酸和血浆Hcy测量和MTHFR基因分型在534 HD患者执行。MTHFR基因型的影响,维生素B12和叶酸在450 HD患者血浆Hcy水平检查不服用维生素B12和叶酸。检查维生素B12在血浆Hcy浓度的影响,我们在HD患者血浆Hcy浓度相比,没有补充维生素B12。检查是否存在功能性维生素B12缺乏症患者即使在高清维生素B12含量正常,15 HD患者(血清维生素B12的浓度,250 - 2100 pg / mL)服用维生素B12 (mecobalamin 1.5 mg / d)为8周。血清浓度methylmalonic酸(MMA)和维生素B12被测量。 Hcy levels were higher and folate levels were lower in patients with the TT and CT genotypes compared with patients with the CC genotype. Analysis of covariance to determine independent predictors of high Hcy levels identified low serum vitamin B12 and folate levels and high albumin (Alb) levels in CC-genotype patients, low folate levels and high Alb levels in CT-genotype patients, and low folate levels in TT-genotype patients. Plasma Hcy levels were lower in CC- and CT-genotype patients with vitamin B12 supplementation than in those without supplementation. Vitamin B12 supplementation for 8 weeks significantly reduced MMA concentrations in HD patients with normal serum vitamin B12 concentrations. These results indicate that MTHFR genotype influences the correlation of Hcy level with vitamin B12 and folate levels in HD patients. Functional vitamin B12 deficiency may exist, even in HD patients with normal vitamin B12 concentrations. The efficacy of vitamin B12 and folate supplementation on plasma Hcy levels may depend on MTHFR genotype.

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药物靶点

药物	目标	类	生物	药理作用	行动
维生素b12	Methylenetetrahydrofolate还原酶	蛋白质	人类	未知的	代数余子式	细节