(强力霉素)。

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Bonnetblanc JM

(强力霉素)。

安北京医学Venereol。2002 Jun-Jul; 129 (6): 874 - 82。

PubMed ID

12218915 (在PubMed

]

文摘

Doxycyclin是半合成四环素类结构异构体。这展览好胞内渗透,在许多细菌有抑菌活性。不同类型或细菌耐药性是已知的。获得性耐药有核糖体或plasmidic机制。电阻的丙酸菌属曼秀雷敦ARNr的突变是次要的。Doxycyclin也有抗炎活动,通过许多途径。Doxycyclin迅速,几乎完全被消化道吸收。食物没有发生吸收。它有一个高但不稳定的亲和力与90 p蛋白。100年的分子联系在一起。它迅速扩散在血管外的隔间和大部分的组织。 Bile excretion is the main excretion route. It occurs more slowly by the kidney with tubular reabsorption. The main dermatological indication is acne with daily dose varing between 50 mg and 100 mg. Although good assays are lacking, a large professional consensus has validated its use. It is also active at the same dosage in rosacea. Chlamydial and mycoplasma urethritis may be treated by doxycyclin, and this antibiotic is presently used as second choice. Many other diseases may be treated as a primary or secondary choice, such as treponematoses, brucellosis, pasteurellosis, borreliosis, rickettsioses and cholera. Some non infectious diseases have been occasionally treated by doxycycline. Digestive side effects are the more frequent. Esophageal toxicity has been reduced with tablets and sufficient concomitant water ingestion. Phototoxicity is dose-dependent. Various cutaneous side effects have been described, some of them severe. Systemic toxicity is rare. Pregnancy is a contra-indication, and as other tetracyclines, it should not be given to children and during lactation. Doxycycline is commercialized as tablets. No reduction of the dose is necessary in renal failure. Association with retinoids is not recommended. Anticoagulants are potentialized. Didanosin, iron, and mineral salts lower its activity.

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强力霉素