漱口水的影响二氧化氯在口腔恶臭和唾液细菌:一项随机安慰剂对照7天的审判。
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Shinada K,上野M, Konishi C, Takehara年代,Yokoyama年代,Zaitsu T, Ohnuki M,赖特FA,川口Y
漱口水的影响二氧化氯在口腔恶臭和唾液细菌:一项随机安慰剂对照7天的审判。
试验。2010年2月12日,十一14。doi: 10.1186 / 1745-6215-11-14。
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20152022 (在PubMed]
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背景:之前的研究表明二氧化氯的氧化性质和微生物保藏(二氧化氯)。其临床功效口腔恶臭的评估和报告只有在短期试验,此外,没有临床研究调查其对牙周微生物保藏和不合法的细菌。因此,本研究的目的是评估的抑制性影响漱口水含有二氧化氯用于7天上午口腔恶臭和唾液牙周和不合法的细菌。方法/设计:随机、双盲、交叉,安慰剂对照试验进行了15名健康男性志愿者,他们分成两组。受试者被要求冲洗与实验包含二氧化氯或安慰剂漱口水漱口水,没有二氧化氯,每天两次,7天。一星期后冲刷时期,每组7天然后使用相反的漱口水。在基线和7天后,口腔恶臭与感官评价测量(OM),并分析了浓度的硫化氢(H2S),甲硫醇(CH3SH)和二甲基硫醚((CH3) 2 s),人类的主要vsc口腔恶臭,由气相色谱(GC)评估。临床结果变量包括斑块和牙龈指数和舌苔指数。唾液样本的微生物调查。定量和定性分析使用聚合酶链reaction-Invader方法。 RESULTS AND DISCUSSION: The baseline oral condition in healthy subjects in the 2 groups did not differ significantly. After rinsing with the mouthwash containing ClO2 for 7 days, morning bad breath decreased as measured by the OM and reduced the concentrations of H2S, CH3SH and (CH3)2S measured by GC, were found. Moreover ClO2 mouthwash used over a 7-day period appeared effective in reducing plaque, tongue coating accumulation and the counts of Fusobacterium nucleatum in saliva. Future research is needed to examine long-term effects, as well as effects on periodontal diseases and plaque accumulation in a well-defined sample of halitosis patients and broader population samples. TRIAL REGISTRATION: ClinicalTrials.gov NCT00748943.
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