奥美拉唑。回顾它的使用在幽门螺杆菌感染,gastro-oesophageal返流性疾病和非甾体类抗炎药引起的消化性溃疡。

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Langtry高清,王尔德MI

奥美拉唑。回顾它的使用在幽门螺杆菌感染,gastro-oesophageal返流性疾病和非甾体类抗炎药引起的消化性溃疡。

药。1998年9月,56 (3):447 - 86。doi: 10.2165 / 00003495-199856030-00012。

PubMed ID

9777317 (在PubMed

]

文摘

未标记的:奥美拉唑是一种研究减少胃酸的分泌的质子泵抑制剂。在幽门螺杆菌感染,本文讨论其使用gastro-oesophageal反流病(GORD)有或没有食管炎和胃肠道损伤引起的非甾体类抗炎药(非甾体抗炎药)。最优anti-H奥美拉唑治疗方案。螺杆菌疗法是那些管理药物的剂量40毫克/天(1或2)/剂量)7,10 - 14天结合2抗菌药物。3-drug方案的一个组成部分,在直接的比较研究,奥美拉唑用兰索拉唑至少一样有效,pantoprazole、铋化合物和雷尼替丁。然而,一个荟萃分析表明,三与奥美拉唑治疗更有效比方案包含雷尼替丁、lansoprazole或铋。奥美拉唑三联疗法似乎也是成功方案用于儿童幽门螺杆菌感染。与食管炎急性GORD患者,用兰索拉唑奥美拉唑至少是一样有效的或pantoprazole促进愈合,优于雷尼替丁,西咪替丁或cisapride食管炎治疗和缓解症状。奥美拉唑是用兰索拉唑相似,优于雷尼替丁在预防食管炎复发患者的食管炎的所有成绩,但可以用兰索拉唑优于或pantoprazole患者更严重的疾病。更多的患者有症状的GORD没有食管炎有经验的短期治疗后症状缓解与雷尼替丁与奥美拉唑,cisapride或安慰剂,症状更容易避免,奥美拉唑比西咪替丁或安慰剂。 Omeprazole was effective in healing and relieving symptoms of reflux oesophagitis in children with oesophagitis refractory to histamine H2 receptor antagonists. Omeprazole is superior to placebo in preventing NSAID-induced gastrointestinal damage in patients who must continue to take NSAIDs. It is also similar to misoprostol and superior to ranitidine in its ability to heal NSAID-induced peptic ulcers and erosions, and superior to misoprostol, ranitidine or placebo in its ability to prevent relapse. In long and short term studies, omeprazole was well tolerated, with diarrhoea, headache, dizziness, flatulence, abdominal pain and constipation being the most commonly reported adverse events. Usual omeprazole dosages, alone or combined with other agents, are 10 to 40 mg/day for adults and 10 to 20 mg/day for children. CONCLUSIONS: Omeprazole is a well studied and well tolerated agent effective in adults or children as a component in regimens aimed at eradicating H. pylori infections or as monotherapy in the treatment and prophylaxis of GORD with or without oesophagitis or NSAID-induced gastrointestinal damage.

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药物

奥美拉唑