相对生物利用度和利用特定形式的B12补充剂与潜在减轻B12-related遗传多态性。
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布雷迪Paul C DM
相对生物利用度和利用特定形式的B12补充剂与潜在减轻B12-related遗传多态性。
中国医疗(恩)。2017年2月,16 (1):42-49。
- PubMed ID
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28223907 (在PubMed]
- 文摘
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背景:三个自然形式的维生素B12是商用:methylcobalamin (MeCbl) adenosylcobalamin (AdCbl)和hydroxycobalamin (OHCbl),所有这些已被证明在临床研究来改善维生素B12的地位。他们瑞金B12形式发生在人体生理学和动物的食物。相比之下,维生素B12 (CNCbl),合成维生素B12化合物用于食品强化和在一些补品,只发生在人体组织微量的氰化物摄入吸烟或其他来源。摘要目的:本研究有3个目标:(1)总结和比较同化途径4 B12形式;(2)确定与特定B12补充剂形式(或组合形式)提出任何优势为普通人群或个体与单核苷酸多态性(snp)在B12-related途径;和(3)解决误解B12形式,甲基化途径,以及各种snp在商用测试报告。设计:PubMed系统寻找文章发表到2016年6月使用特定的关键字。人类、动物和体外研究发表在英语、法语和德语都包括在内。其他研究认为被发现通过选择在PubMed提出“相关研究”并引用一些研究。背景:研究发生在洛杉矶,加州,美国。 RESULTS: The studies reviewed provide evidence that all supplemental or food-derived B12 forms are reduced to a core cobalamin molecule, which converts to the intracellular active forms: MeCbl and AdCbl, in a ratio not influenced by the form of B12 ingested. The methyl and adenosyl components of supplemental MeCbl and AdCbl are cleaved inside cells and are not used in the synthesis of intracellular MeCbl and AdCbl, respectively. However, the overall bioavailability of each form of supplemental B12 may be influenced by many factors such as gastrointestinal pathologies, age, and genetics. Polymorphisms on B12-related pathways may affect the efficiency of absorption, blood transport, cellular uptake, and intracellular transformations. CONCLUSIONS: Supplementing with any of the nature bioidentical forms of B12 (MeCbl, OHCbl, and/or AdCbl) is preferred instead of the use of CNCbl, owing to their superior bioavailability and safety. For the majority of the population, all B12 forms may likely have similar bioavailabilities and physiological effects; thus, it makes sense to employ the least-expensive form of B12, such as MeCbl. Individuals with particular single nucleotide polymorphisms (SNPs) affecting B12 assimilation may raise their B12 status more efficiently with 1 or more particular forms of vitamin B12. However, because those types of SNPs are not currently reported in commercial tests, individuals may require either a trial-and-error approach by supplementing with 1 particular form of B12 at a time, or they might simply use a supplement with a combination of all 3 naturally occurring forms of B12 that are commercially available for a better chance of achieving faster clinical results. That approach may or may not offset genetic polymorphisms involving B12 metabolism and related pathways.
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