Agomelatine治疗重度抑郁症。

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Dolder CR,纳尔逊M,斯奈德M

Agomelatine治疗重度抑郁症。

安Pharmacother。2008年12月,42(12):1822 - 31所示。doi: 10.1345 / aph.1L296。Epub 2008年11月25日。

PubMed ID

19033480 (在PubMed

]

文摘

目的:评估疗效、安全性、药理学和药代动力学数据agomelatine更好地理解其潜在作用治疗重度抑郁症患者。数据来源:MEDLINE搜索(1966 - 2008年10月)进行了使用以下术语:agomelatine,抗抑郁,S20098,褪黑素,血清素,5 - (2 c),太,功效,安全,副作用,药理学、药代动力学、受体结合,抑郁,重度抑郁症,情绪障碍。研究选择和数据提取:所有文章的英文标识数据源进行评估。随机对照试验涉及人类优先审查。发表文章的引用中确定初始搜索过程也进行任何额外的研究适合审查。数据综合:Agomelatine,一个强有力的兴奋剂在1型和2褪黑激素受体,选择性地抑制5 -羟色胺。它是通过细胞色素P450 isoenyzmes广泛代谢1 a1, a2,和2 c9与活动比父药物代谢物。五个随机对照研究发现,检查agomelatine在重度抑郁症的疗效和安全性。一般来说,agomelatine被发现产生显著改善抑郁症状与安慰剂比较多,但不是全部,等级量表。三个试验的活动比较器武器(ie、文拉法辛、帕罗西汀)。 In these 3 investigations, agomelatine produced effects on depressive symptoms similar to those of the comparator drugs. A small number of studies have demonstrated sleep benefits with the use of agomelatine in depressed patients. Positive findings also exist for the use of agomelatine in seasonal affective disorder and bipolar depression. The most common adverse effects reported with agomelatine use were headache, nasopharyngitis, and gastrointestinal complaints. The magnitude of agomelatine-related adverse effects appears to be at least similar to some currently marketed antidepressants. CONCLUSIONS: Overall, agomelatine is a promising and well-tolerated medication for the treatment of major depressive disorder. More large-scale controlled trials are needed to gain a better understanding of the relative efficacy and safety of agomelatine.

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药物酶

药物	酶	类	生物	药理作用	行动
Agomelatine	细胞色素P450 2 c9	蛋白质	人类	未知的	抑制剂	细节