Ketorolac,注射nonnarcotic镇痛。

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Litvak公里,McEvoy星期

Ketorolac,注射nonnarcotic镇痛。

中国制药。1990;12月9 (12):921 - 35。

PubMed ID

2292174 (在PubMed

]

文摘

可注射的临床研究非甾体类抗炎剂(NSAIA) ketorolac氨丁三醇,化学,药理学,药物动力学,药物相互作用和不良反应ketorolac。Ketorolac展品抗炎、止痛和退热的活动。虽然行动的确切机制目前还不清楚,其效果似乎主要是抑制前列腺素的合成有关。口服后,i.m.。或静脉输液管理,ketorolac及其代谢物主要在尿液中排出。Ketorolac氨丁三醇已被用于中度到重度的术后疼痛的缓解症状,包括腹部、妇科、口腔、骨科、泌尿道的手术。Ketorolac也被用于缓解急性肾绞痛,疼痛与创伤有关,和发自内心的痛苦与癌症有关。当i.m.管理。,ketorolac产生镇痛与哌替啶贝聿铭剂量、镇痛新或吗啡。最常见的不良反应与短期政府相关神经系统和胃肠道的影响; these are usually mild and occur in about 39% of patients. Unlike opiate analgesics, ketorolac does not appear to cause tolerance or physical dependence in patients receiving long-term therapy. Ketorolac tromethamine has been administered concomitantly with morphine or meperidine without apparent adverse interaction. For short-term pain management, an initial i.m. ketorolac tromethamine loading dose of 30 or 60 mg is recommended. Ketorolac tromethamine appears to be as effective as morphine or meperidine for short-term management of moderate to severe postoperative pain. It lacks the respiratory depressant effects of opiate analgesics but shares the toxic potentials of other NSAIAs.

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药物

Ketorolac