治疗胃食管返流疾病。

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治疗胃食管返流疾病。

制药科学。2005年12月,27 (6):432 - 5。doi: 10.1007 / s11096 - 005 - 4798 - 7。

PubMed ID

16341949 (在PubMed

]

文摘

审查的未标记的:目的和方法:本文汇集了关于治疗胃食管返流疾病的信息。从Medline出版的手稿被确定。文章被包含在评审前筛查相关性。结果与结论:据估计,有40%的人在西方国家经常体验心痛,最典型的症状的胃食管反流病(GERD)。选择治疗GERD从场外交易(OTC)抗酸药到质子泵抑制剂(ppi)和抗反流手术。许多患者用药与OTC药物如抗酸药和低剂量组胺H2-receptor拮抗剂(H2RA)来缓解情景或食品相关GERD症状,,不得寻求医疗建议,除非症状持续或恶化。然而,胃食管反流病是一种慢性疾病,经常影响健康相关的生活质量和,如果管理不当,GERD的并发症可能包括腐蚀性食管炎(EO),巴雷特食管腺癌。适当控制酸的分泌是成功治疗的关键条件。OTC药物提供有效的缓解症状,约四分之一的患者患有GERD。beplayappH2RAs还可以提供有效的缓解症状,尤其是在温和的GERD患者,但随着时间的推移变得不那么有效。 PPIs are the agents of choice for the suppression of gastric acid production and have become the mainstay of therapy for acid-related diseases. PPIs produce significantly faster and more complete symptomatic relief, significantly faster and more complete healing of erosive GERD compared with H2RAs and are also significantly more effective at preventing relapse of EO. There are a number of existing guidelines for the treatment of GERD. Recommendation for initial therapy consist of general measures, such as lifestyle advice in combination with antacids and/or alginates. When general measures fail, the next step is empirical therapy. Two options exist for the expirical treatment of GERD, so-called "step-up" or "step-down" therapy. There are no clear data to support either treatment strategy as a universal approach to all patients; consequently, physicians must always choose the course best suited to the individual patient.

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雷尼替丁