在大鼠子宫Octreotide抑制髓过氧物酶活动。

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Alatas E, Alatas O, Colak O

在大鼠子宫Octreotide抑制髓过氧物酶活动。

学报。Gynecol Scand。2000年7月,79 (7):524 - 7。

PubMed ID

10929949 (在PubMed

]

文摘

摘要目的:一些研究表明,合成somatostatin-analog octreotide可能影响下丘脑的功能,前垂体和卵巢。到目前为止,很少有研究octreotide子宫功能的影响的报告。我们调查了在大鼠子宫octreotide对中性粒细胞功能的影响。方法:20 Sprague-Dawley老鼠受到标准化子宫角切除。评估octreotide的影响,老鼠被随机分配治疗(octreotide 20 microgr /公斤,SC)和对照组。两周后relaparotomy和侧子宫角切除在执行相同的标准方式。切除部分在冷生理盐水洗,立即在液态氮冷冻和均质。髓过氧化酶(MPO)和弹性蛋白酶浓度测定在子宫角匀浆。Mann-Whitney你测试的数据进行了分析。结果:在octreotide-treated老鼠MPO活性显著降低后14天(14.79 + / - -2.08和6.62 + / - -1.72 U /毫克蛋白; p=0.012). There was also a significant difference in mean MPO levels between the two groups at the end of the experiment (6.62+/- 1.72 versus 18.56+/-2.49 U/mg protein; p=0.001). The octreotide administration did not affect elastase levels significantly. No differences were found in mean elastase levels in both groups after the treatment. CONCLUSION: This study demonstrates that octreotide has a significant effect on the neutrophil function in terms of MPO activity in rat uterus. Further studies are needed to clarify the clinical relevance of the inhibitory effect of octreotide in the uterus and the possibility of its applications.

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药物酶

药物	酶	类	生物	药理作用	行动
Octreotide	髓过氧物酶	蛋白质	人类	未知的	抑制剂	细节