8 -羟基喹啉。杀死non-replicating结核分枝杆菌的

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Darby厘米,内森CF

8 -羟基喹啉。杀死non-replicating结核分枝杆菌的

J Antimicrob Chemother。2010年7月,65 (7):1424 - 7。doi: 10.1093 /江淮/ dkq145。Epub 2010年4月30日。

PubMed ID

20435781 (在PubMed

]

文摘

目的:确定8 -羟基喹啉(8总部)的影响在non-replicating结核分枝杆菌(Mtb)相比,其报道影响结核分枝杆菌复制。方法:复制H37Rv Mtb的麦克风8总部决定采用7 h9误事。结核分枝杆菌杀菌活动是由暴露H37Rv 8总部4天的情况下,否则允许指数复制(O (2) 20%, pH值6.6)和条件复制是杜绝:O (2) 1%, pH值6.6;O (2) 20%, pH值5.5;或20% O (2), pH值5.5,0.5毫米亚硝酸钠。7日连续稀释是镀h11琼脂量化cfu。电阻()确定频率> 10 h9 7日镀(9)细菌的琼脂板包含2 x麦克风8总部。结果:8总部有效地对抗结核分枝杆菌复制(microM麦克风2.5,0.36 mg / L)。在复制和non-replicating条件下,cfu被>减少4天或= 5日志(10)在最高浓度测试(10 microM)。在低pH值杀菌活性最大,8总部cfu减少了1 - 1.5在1 microM日志(10)。 We were unable to recover any 8HQ-resistant colonies. CONCLUSIONS: This study demonstrates that 8HQ has bactericidal activity of comparable potency against non-replicating and replicating Mtb, a property not observed for anti-infective agents currently approved for treatment of tuberculosis, and a very low FOR. Drugs with these properties are urgently needed to shorten the course of treatment for both active and latent tuberculosis.

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