dutasteride要优于非那雄胺的头发再生和逆转小型化与雄性遗传脱发的男性:随机对照开放evaluator-blinded研究。
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Shanshanwal SJ, Dhurat RS
dutasteride要优于非那雄胺的头发再生和逆转小型化与雄性遗传脱发的男性:随机对照开放evaluator-blinded研究。
印度北京医学Venereol Leprol。2017; 1 - 2月83 (1):47-54。doi: 10.4103 / 0378 - 6323.188652。
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27549867 (在PubMed]
- 文摘
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背景:非那雄胺和dutasteride抑制剂的酶α还原二氢睾酮抑制睾酮的转换。Dutasteride抑制I型和II型α还原而非那雄胺抑制酶II型。同功酶存在于毛囊,很可能比非那雄胺dutasteride更有效。目的:比较疗效、安全性和耐受性与雄性遗传脱发dutasteride和非那雄胺的男人。方法:雄性遗传脱发的男性在18岁至40岁之间被随机分配接受0.5毫克每日dutasteride或1毫克非那雄胺为24周。变量的主要功效是头发计数(厚薄)从修改phototrichograms目标区域和全球摄影评估失明和破盲调查员。次要疗效变量是使用一个预设问卷主观评价。患者评估每月的副作用。结果:九十例男性雄性遗传脱发患者招募。每厘米头发总数的增加[2]代表新的增长明显高于dutasteride组(基线- 223的头发; at 24 weeks- 246 hair) compared to finasteride group (baseline- 227 hair; at 24 weeks- 231 hair). The decrease in thin hair count per cm[2] suggestive of reversal of miniaturization was significantly higher in dutasteride group (baseline- 65 hair; at 24 weeks- 57 hair) compared to finasteride group (baseline- 67 hair; at 24 weeks- 66 hair). Both the groups showed a similar side effect profile with sexual dysfunction being the most common and reversible side effect. LIMITATIONS: Limitations include the short duration of the study (6 months), the small sample size and the fact that it was an open-label study. CONCLUSIONS: Dutasteride was shown to be more efficacious than finasteride and the side-effect profiles were comparable.
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