管理Doxazosin distal-ureteral石头。

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Liatsikos EN, Katsakiori PF, Assimakopoulos K, Voudoukis T, Kallidonis P, Constantinides C, Athanasopoulos, Stolzenburg JU, Perimenis P

管理Doxazosin distal-ureteral石头。

J Endourol。2007; 21 (5): 538 - 41。doi: 10.1089 / end.2006.0107。

PubMed ID

17523910 (在PubMed

]

文摘

目的:评价的功效doxazosin诱导自发通过石头的远端输尿管并比较其疗效根据石头的大小。患者和方法:七十三例患者平均年龄为46.38 + / - 10.17岁,distal-ureteral石头被分成四组根据石头的大小和药物治疗:< 5毫米不doxazosin (a组;n = 15);5 - 10毫米(B组;n = 16);< 5毫米doxazosin 4毫克/天4周(C组;n = 20);和5 - 10毫米doxazosin 4毫克/天4周(D组;n = 22)。组A和B作为控制组C和D,分别。 RESULTS: Spontaneous stone passage was documented in 9 patients (60%) in group A v 17 (85%) in group C (P=0.047) and 7 (43.75%) in group B v 16 (72.73%) in group D (P=0.036). The average expulsion time was 8.78 +/- 1.09 days in group A v 7.59 +/- 0.80 days in group C (P=0.004) and 12.14 +/- 1.35 days in group B v 7.06 +/- 1.29 days in group D (P<0.0001). The number of pain episodes in group D patients was significantly lower than in group B (P +/- 0.0078). CONCLUSIONS: Doxazosin treatment proved to be safe and effective for distal-ureteral stones, as determined by earlier expulsion, decreased colic frequency, and absence of side effects. The efficacy of doxazosin was significantly higher for 5-to 10-mm stones than for smaller ones.

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药物

Doxazosin