氟西汀:serotonin-specific,第二代抗抑郁药。

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Sommi RW, Crismon ML,鲍登CL

氟西汀:serotonin-specific,第二代抗抑郁药。

药物治疗。1987;1 - 2月7 (1):1 - 15。

PubMed ID

3554156 (在PubMed

]

文摘

氟西汀是一个双环抗抑郁药,是一个特定的和强有力的突触前的5 -羟色胺再摄取抑制剂。它本质上不会影响去甲肾上腺素的再摄取或其他神经递质。同样,对神经递质受体网站微不足道的亲和力。口服后吸收良好,绝对生物利用度的狗大约72 + / - 27.6%。平均最高温度是4至8小时,大约94%的蛋白质绑定。一剂后,消除半衰期是1 - 3天。在长期的管理,消除半衰期平均4天。其药物动力学非线性出现。代谢是一个活跃的代谢物norfluoxetine,也是具体的抑制5 -羟色胺再摄取。Norfluoxetine消除半衰期平均7天之后的长期管理。 Little is known about potential drug interactions; however, fluoxetine appears to have minimal clinically relevant interactions. Fluoxetine is indicated in the treatment of major depression. Its efficacy is comparable to the tricyclics and it has a similar onset of action. Although doses as high as 80 mg/day have been used, the optimal dosage range appears to be 20-40 mg once daily. Fluoxetine has been used with success in obsessive-compulsive disorder and intention myoclonus, however, its use in these disorders remains investigational. The frequency of side effects is low and dose related; the most common effects are nausea, anxiety, insomnia, anorexia, diarrhea, nervousness, and headache. Eight reports of intentional overdose with fluoxetine alone resulted in no deaths and mild adverse effects. It will be marketed as 20-mg capsules under the brand name of Prozac. Although fluoxetine should be added to formularies, its use should be reserved for treatment of those who do not respond to or do not tolerate tricyclic agents.

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药物

氟西汀