氟化物耗尽口服引起酸化的类群,但不会在小鼠肠道微生物群落。
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Yasuda K,许T,加利尼CA,干LJ, Schwager E,史,DuLong CR、Schwager RN,阿布·阿里GS, Franzosa EA,加勒特WS Huttenhower C,摩根XC
氟化物耗尽口服引起酸化的类群,但不会在小鼠肠道微生物群落。
mSystems。2017年8月8日;2 (4)。pii: mSystems00047-17。doi: 10.1128 / mSystems.00047-17。eCollection 2017 Jul-Aug。
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28808691 (在PubMed]
- 文摘
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饮用水的氟化反应和牙科产品防止龋齿主要通过抑制能量收获口服生龋齿的细菌(如变形链球菌和链球菌杂志),从而导致他们的损耗。然而,口腔和肠道微生物群落在多大程度上影响主机接触氟化物的勘探。在这项研究中,我们模仿人类氟暴露市政水和牙科产品治疗小鼠低或高水平的氟化物超过12周。然后我们使用16 s rRNA基因扩增子和猎枪宏基因组测序来评估氟对口腔和肠道微生物组成和功能的影响。在低收入和高氟组,几个操作分类单元(辣子鸡)引起酸化的细菌属(如Parabacteroides、拟杆菌和Bilophila)在口腔耗尽社区。此外,fluoride-associated口腔社区组成的变化导致损耗的基因家族参与中心碳代谢和能量收获(2-oxoglutarate铁氧还蛋白氧化还原酶,琥珀酸脱氢酶,和乙醛酸循环)。相比之下,氟化物治疗没有诱导肠道微生物群落组成的一个重要转变或功能在我们的小鼠模型,可能由于在上消化道吸收。Fluoride-associated扰动从而似乎选择性影响口腔的成分而不是在小鼠肠道微生物群落。未来的研究将需要了解可能影响人类微生物组的接触氟化物。氟化重要性已添加到饮用水和牙科产品自1950年代。 The beneficial effects of fluoride on oral health are due to its ability to inhibit the growth of bacteria that cause dental caries. Despite widespread human consumption of fluoride, there have been only two studies of humans that considered the effect of fluoride on human-associated microbial communities, which are increasingly understood to play important roles in health and disease. Notably, neither of these studies included a true cross-sectional control lacking fluoride exposure, as study subjects continued baseline fluoride treatment in their daily dental hygiene routines. To our knowledge, this work (in mice) is the first controlled study to assess the independent effects of fluoride exposure on the oral and gut microbial communities. Investigating how fluoride interacts with host-associated microbial communities in this controlled setting represents an effort toward understanding how common environmental exposures may potentially influence health.