联系SLCO1B1 T521C多态性和statin-induced肌病的风险:一个荟萃分析。

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湘问,陈平方,Ma LY,胡锦涛K,张Z,μGY,谢QF,张XD,崔

联系SLCO1B1 T521C多态性和statin-induced肌病的风险:一个荟萃分析。

药物基因组学j . 2018; 12月18 (6):721 - 729。doi: 10.1038 / s41397 - 018 - 0054 - 0。Epub 2018年9月24日。

PubMed ID

30250148 (在PubMed

]

文摘

大量研究之间的关系说明SLCO1B1 T521C多态性和statin-induced肌病风险;然而,这种关联并不一致。三个电子数据库(PubMed、EMBASE, Cochrane图书馆)是搜索从开始到2017年10月来识别潜在的研究。摘要优势比(ORs) 95%的置信区间(CIs)从不同的遗传模型计算通过使用一个随机模型。14个研究组成3265肌病病人和7743个对照组被包括在内。摘要口服补液盐建议521 cc (OR: 2.31;95%置信区间:1.15—-4.63;P = 0.019), 521 tc (OR: 1.34;95%置信区间:1.02—-1.76;P = 0.034), 521 cc + TC (OR: 1.82; 95% CI: 1.32-2.51; P < 0.001) were associated with a greater risk of statin-induced myopathy than 521TT. The higher incidence of statin-induced myopathy was found to be significantly correlated with the C allele compared with the T allele (OR: 1.89; 95% CI: 1.36-2.62; P < 0.001). In addition, we observed that 521CC + TC was associated with an increased risk of myopathy in individuals who received simvastatin (OR: 2.35; 95% CI: 1.08-5.12; P = 0.032) or rosuvastatin (OR: 1.69; 95% CI: 1.07-2.67; P = 0.024) when compared with 521TT. The 521C allele was associated with a greater risk of cerivastatin-induced myopathy than the T allele (OR: 1.95; 95% CI: 1.47-2.57; P < 0.001). The findings of this study indicated that SLCO1B1 T521C was associated with a significantly higher risk of statin-induced myopathy, especially for simvastatin, rosuvastatin, and cerivastatin. Future studies should be conducted in subjects receiving specific types of drugs, and any potential adverse events need to be explored.

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药物

洛伐他汀

药物转运蛋白

药物	转运体	类	生物	药理作用	行动
洛伐他汀	溶质载体有机阴离子转运蛋白家族成员1 b1	蛋白质	人类	未知的	底物 抑制剂	细节