非那吡啶:术前鉴别输尿管孔的方法。
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史密斯Rehfuss,马洪J, Sorokin我,C,斯坦BS
非那吡啶:术前鉴别输尿管孔的方法。
泌尿学。2018年5月,115:36-38。doi: 10.1016 / j.urology.2018.02.023。Epub 2018 3月1。
- PubMed ID
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29501712 (在PubMed]
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目的:确定很难看到输尿管孔(uo),泌尿科医师需要一个方法来染色的尿液。非那吡啶,尿镇痛较尿液橙色,可以口服术前。我们在确定uo非那吡啶的有效性进行评估,管理上的最佳时机。方法:成年患者进行内镜程序Stratton VA的前瞻性。术前代谢面板进行了综述。排除标准是肾功能不全(肌酐清除率< 50毫升/分钟),重型肝炎或严重的肝脏疾病,glucose-6-phosphate脱氢酶缺乏症,以前过敏非那吡啶,或怀孕。在第一阶段,病人接受办公室软性膀胱镜检查是服用200毫克非那吡啶的早晨过程。因为健壮的橙色的尿液,第二阶段实施。在阶段2中,接受严格的膀胱镜检查的患者在手术室了200毫克非那吡啶在手术前一天晚上7点。在进入膀胱,uo被识别和尿液颜色分级(0 =没有染色,1 =弱,2 =温和,和3 =强烈)。 Patients were assessed postoperatively for side effects. RESULTS: Five patients were included in phase 1. The mean time from medication to cystoscopy was 153 minutes (range 17-304 minutes). One-third of patients had excretion of grade 3 orange urine that obscured inspection of the bladder mucosa. The study design was adjusted and we transitioned to phase 2. Twenty-three patients were enrolled in phase 2. The mean time from phenazopyridine dose to cystoscopy was 14 hours (range 13-17 hours). Seventy-three percent of patients had grade 2 efflux from the UOs. CONCLUSION: Phenazopyridine can successfully identify UOs and can be administered as early as the evening before the procedure.
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