呋喃苯胺酸:进步在理解其利尿、抗炎和行动bronchodilating机制,用于呼吸道疾病的治疗。

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Prandota J

呋喃苯胺酸:进步在理解其利尿、抗炎和行动bronchodilating机制,用于呼吸道疾病的治疗。

2002 J。Jul-Aug; 9 (4): 317 - 28。

PubMed ID

12115021 (在PubMed

]

文摘

积累的实验和临床数据表明,肾上腺皮质甾类和/或内源性ouabain-like物质可能发挥重要作用的机理速尿利尿作用。据报道,该药物是高度绑定在肾上腺,肺、肾、脾、肝。肝硬化患者,呋喃苯胺酸产生了显著减少尿钠排泄的影响与正常人相比,等离子体的循环内皮素水平和心房利钠因子(曾帮工)显著升高。在新生儿,之后政府呋喃苯胺酸,尿排泄endothelin-1和醛固酮显著增加,而众所周知,内皮素可能释放曾帮工和醛固酮剂量依赖性的方式。呋喃苯胺酸被用来刺激球状带,而曾帮工减少生产类固醇在球状带和下方细胞培养由于各种因素刺激。因为随之而来的使用曾帮工和呋喃苯胺酸似乎diuretically有效的新生儿心脏手术之后,你可能表明,呋喃苯胺酸与曾帮工的竞争对肾上腺的影响。呋喃苯胺酸由吸入对过敏和常年nonallergic鼻炎产生保护作用,有效预防鼻息肉病的手术后的复发。这种药物也可以用作平喘药代理。在早产婴儿ventilator-dependent慢性肺病、雾化速尿利尿改善肺功能无明显影响。在成人和儿童哮喘、呋喃苯胺酸产生保护作用对几种间接刺激引起的支气管收缩色甘酸二钠或nedocromil相似。 Aerosolized furosemide had a preventive effect also on bronchoconstriction induced by inhaled lysine acetylsalicylate in patients with aspirin-sensitive asthma. In high-dose beclomethasone-dependent asthma, inhaled lysine acetylsalicylate and furosemide exerted a mutually potentiating antiasthmatic activity, allowing considerable sparing of the inhaled steroid. It is proposed that this effect may be explained by the corticosteroid-sparing action of lysine released from the lysine acetylsalicylate molecule because similar beneficial effects were also obtained after the concomitant use of epsilon-aminocaproic acid (whose chemical structure is almost the same as that of lysine) and prednisone. Furosemide exhibited an anti-inflammatory effect through inhibition of production and release of cytokines interleukin (IL)-6, IL-8, and tumor necrosis factor-alpha from peripheral mononuclear cells, which may have a beneficial effect on local inflamed tissue imbalance in the ratio of different cytokines, thus improving the sensitivity of target cells to endogenous glucocorticosteroids.

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药物

呋喃苯胺酸