Mini-dose (1-microCi) 14 c-urea呼吸检测幽门螺杆菌的检测。

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Raju GS,史密斯MJ,莫顿D,巴德汉KD

Mini-dose (1-microCi) 14 c-urea呼吸检测幽门螺杆菌的检测。

杂志。1994年7月,89(7):1027 - 31所示。

PubMed ID

8017360 (在PubMed

]

文摘

目的:开发和评估一个mini-dose (1-microCi) 14 c-urea呼气试验(UBT),使用一个简化的协议。方法:患者禁食(n = 95)有喝1 microCi 14 c-urea (37 kBq)。呼吸样本收集二氧化碳(2更易)10,20日和30分钟后被困在季铵盐溶液;14 c活动被液体闪烁计数测量。结果表示为“二氧化碳”复苏,即。,((%的服用剂量恢复/更易与二氧化碳困)x体重(公斤)]。再现性测试评估的重复研究连续两天在11个志愿者。所有呼吸测试结果与幽门螺杆菌的文化。在27个病人,结果也与13 c-urea呼吸测试(欧洲协议)。结果:使用接收器操作符(ROC)分析特点,我们选择的截止值0.55 20分钟为幽门螺旋杆菌分离那些积极的和消极的。 Sensitivity and specificity were 98% and 87%, respectively. Among four patients with negative culture but positive 14C-breath tests, three had evidence of infection by serology or 13C-UBT. Assuming that these three were genuinely positive, the recalculated specificity improved to 97%, sensitivity remaining at 98%. The reproducibility of the test was good, with only a minor day-to-day variation. Concordance with the 13C-UBT was excellent: there was 100% agreement in the diagnostic classification of all 27 patients (19 positive, eight negative). CONCLUSIONS: The mini-dose 14C-urea breath test has a high diagnostic accuracy (sensitivity 98%, specificity 97%) with minimal radiation exposure. It is simple, rapid, and convenient for a busy general hospital.

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药物

尿素c13

尿素碳14