生物运动学和成像和生长激素抑制素受体的宠物放射性配体(68)Ga-DOTATOC:初步数据。

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R,霍夫曼M, Maecke H,波尔纳Weckesser E, Schoffski P, Oei L,舒马赫J, Henze M, Heppeler, Meyer J,克纳普H

生物运动学和成像和生长激素抑制素受体的宠物放射性配体(68)Ga-DOTATOC:初步数据。

J诊断欧元。2001年12月,28 (12):1751 - 7。doi: 10.1007 / s002590100639。Epub 2001年10月31日。

PubMed ID

11734911 (在PubMed

]

文摘

生长激素抑制素(SMS)闪烁扫描法广泛用于神经内分泌肿瘤的检测和分期。由于其优越的成像特性,有越来越多的兴趣使用正电子发射断层扫描(PET)技术对短信显像。本研究解决DOTATOC镓- 68的生产,检测其生物运动学和临床表现SMS-positive肿瘤和转移。准备协议开发,收益率报40%(68)的总体整合Ga肽(DOTATOC)。列过滤后,放射化学纯度超过98%。八个组织学检查证实类癌肿瘤患者注射80 - 250兆贝可示踪剂。宠物收购后立即开始进行管理和直到3 h后注入。使用标准化的吸收值和目标图像量化非目标比率。(68)Ga-DOTATOC宠物之前,所有的病人接受了铟- 111 octreotide平面和单光子发射层析成像(SPET)。动脉活动消除bi-exponential,半衰期为2.0(+ / - -0.3)分钟48(+ / 7)分钟。未发现放射性代谢物在4 h血清中。 Maximal tumour activity accumulation was reached 70+/-20 min post injection. Kidney uptake averaged <50% compared with spleen uptake. Of 40 lesions predefined by computed tomography and/or magnetic resonance imaging, (68)Ga-DOTATOC PET identified 100%, whereas (111)In-octreotide planar and SPET imaging identified only 85%. Tumour to non-tumour ratios ranged from >3:1 for liver ((111)In-octreotide: 1.5:1) to 100:1 for CNS ((111)In-octreotide: 10:1). With (68)Ga-DOTATOC >30% additional lesions were detected. It is concluded that PET using (68)Ga-DOTATOC results in high tumour to non-tumour contrast and low kidney accumulation and yields higher detection rates as compared with (111)In-octreotide scintigraphy.

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药物

Edotreotide镓ga - 68