生长激素抑制素受体阳性肿瘤检测使用新的99 mtc-tricine-hynic-d-phe1-tyr3-octreotide: 111 in-dtpa-d-phe1-octreotide首次在患者和比较结果。

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Bangard M,提出M, Guhlke年代,Otte R,本德H, Maecke人力资源,Biersack HJ

生长激素抑制素受体阳性肿瘤检测使用新的99 mtc-tricine-hynic-d-phe1-tyr3-octreotide: 111 in-dtpa-d-phe1-octreotide首次在患者和比较结果。

J诊断欧元。2000年6月,27 (6):628 - 37。doi: 10.1007 / s002590050556。

PubMed ID
10901448 (在PubMed
]
文摘

铟- 111标记DTPA-D-Phe1-octreotide (DTPA-OC OctreoScan)被引入临床常规检测生长抑素受体(SSTR)阳性的肿瘤,主要是神经内分泌的起源。潜在的进一步应用在其他SSTR-positive癌症(如小细胞肺癌、乳腺癌、黑色素瘤)已经有限的主要是通过限制可用性和放射性核素的高成本。以前曾试图引进锝99 m标记类似物octreotide没有很成功的标签的过程中,体内biodistribution和/或肿瘤检测功能。本研究的目的是评估性能的新型99 mtc-labelled模拟HYNIC-D-Phe1-Tyr3-octreotide (HYNIC-TOC),利用tricine co-ligand, SSTR-positive肿瘤检测的病人与111 in-dtpa-oc相比。总的来说,使用99 mtc-tricine-hynic-toc 13个病人检查。12个患者证明SSTR-positive肿瘤,而一个病人提供SSTR-negative肿瘤。在9日的13个病人两种示踪剂(99 mtc-tricine-hynic-toc和111 in-dtpa-oc)。串行全身扫描,发现观点和/或进行单光子发射断层扫描研究。图像定性和作用(ROI)进行了分析评估。99年biodistribution mtc-tricine-hynic-toc患者显示肾脏的高生理吸收,适度吸收在肝脏和脾脏和小在肠道吸收。 The tracer showed predominantly renal and negligible hepatobiliary excretion. Known SSTR-positive tumour sites showed rapid and intense tracer accumulation. 99mTc-tricine-HYNIC-TOC demonstrated rapid tissue uptake within the first hour after injection and had basically no significant clearance (<20%) from normal or tumour tissue thereafter. In contrast, 111In-DTPA-OC showed continuous clearance from normal tissues as well as renal and very little hepatobiliary excretion. Nevertheless, the patterns of accumulation of 99mTc-tricine-HYNIC-TOC in tumours and normal organs were comparable to those of 111In-DTPA-OC. A lesion-by-lesion comparison showed comparable tumour detection capabilities in intrahepatic tumour sites and superior capabilities of 99mTc-tricine-HYNIC-TOC in respect of extrahepatic lesions. In conclusion, 99mTc-tricine-HYNIC-TOC shows promise as a tracer for SSTR imaging, given its favourable clinical characteristics (specific and high receptor affinity, good biodistribution, renal excretion, low radiation exposure, high imaging quality, on-demand availability) and cost-effectiveness. 99mTc-tricine-HYNIC-TOC allows earlier diagnosis (10 min-4 h) compared with 111In-DTPA-OC (4-24 h).

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