方法学考虑定量18 f-fdg PET / CT在健康受试者对肝葡萄糖代谢的研究。

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穆勒Tragardh M, N,索伦森M

方法学考虑定量18 f-fdg PET / CT在健康受试者对肝葡萄糖代谢的研究。

J诊断。2015年9月,56 (9):1366 - 71。doi: 10.2967 / jnumed.115.154211。Epub 2015 7月9。

PubMed ID

26159590 (在PubMed

]

文摘

未标记的:宠物与葡萄糖模拟(18)F-FDG是用来测量区域组织代谢葡萄糖。然而,(18)F-FDG可能不同于那些具有亲和性的葡萄糖为质膜转运蛋白和胞内酶;集总常数(LC)可以用来纠正这些差异活动。本研究的目的是调查的可行性测量人类肝葡萄糖代谢与动态(18)F-FDG PET / CT和决定一个操作信用证(18)F-FDG相比(3)H-glucose测量。方法:8个健康的人类受试者包括在内。在所有的研究中,(18)F-FDG和(3)H-glucose在盐水和coadministered混合。点动态宠物记录180分钟的肝脏进行血液取样导管肝静脉和桡动脉(浓度F-FDG(18)和(3)H-glucose血)。肝血流量是由吲哚菁绿输液。首先,3主题进行了研究比较丸示踪剂在hyperinsulinemic-euglycemic夹紧和constant-infusion管理局管理。接下来,5科目进行了研究比较禁食和hyperinsulinemic-euglycemic与示踪剂注入夹紧。 Splanchnic extraction fractions of (18)F-FDG (E*) and (3)H-glucose (E) were calculated from concentrations in blood, and the LC was calculated as ln(1 - E*)/ln(1 - E). Volumes of interest were drawn in the liver tissue, and hepatic metabolic clearance of (18)F-FDG (mL of blood/100 mL of liver tissue/min) was estimated. RESULTS: For bolus versus infusion, E* values were always negative when (18)F-FDG was administered as a bolus and were always positive when it was administered as an infusion. For fasting versus clamping, E* values were positive in 4 of 5 studies during fasting and were always positive during clamping. Negative extraction fractions were ascribed to the tracer distribution in the large volume of distribution in the prehepatic splanchnic bed. The LC ranged from 0.43 to 2.53, with no significant difference between fasting and clamping. CONCLUSION: The large volume of distribution of (18)F-FDG in the prehepatic splanchnic bed may complicate the analysis of dynamic PET data because it represents the mixed tracer input to the liver via the portal vein. Therefore, dynamic (18)F-FDG data for human hepatic glucose metabolism should be interpreted with caution, but constant tracer infusion seems to yield more robust results than bolus injection.

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药物

Fludeoxyglucose (18 f)