头孢呋辛axetil。回顾其抗菌活性、药代动力学属性和治疗效果。

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佩里厘米,Brogden RN

头孢呋辛axetil。回顾其抗菌活性、药代动力学属性和治疗效果。

药。1996年7月,52 (1):125 - 58。

PubMed ID

8799689 (在PubMed

]

文摘

头孢呋辛axetil是口服头孢菌素迅速水解活性母体化合物,头孢呋辛。头孢呋辛有广泛的体外抗菌活性包括methicillin-sensitive葡萄球菌和常见的呼吸道病原体肺炎链球菌,流感嗜血杆菌,莫拉克斯氏菌属(布兰汉氏球菌属)复活和组beta-haemolytic链球菌。头孢呋辛兑beta-lactamase广泛活动积极的呼吸道病原体流感嗜血杆菌和复活;这也是积极反对penicillin-susceptible和中间肺炎链球菌菌株。在临床试验中,头孢呋辛axetil每天两次(管理)已经被评估在上、下呼吸道感染的治疗,并演示了其抗菌药物,建立疗效相似,包括阿莫西林/克拉维酸和氯氨苄青霉素。5天的治疗与头孢呋辛axetil最近被证明是有效的为10天的治疗与头孢呋辛axetil或阿莫西林/克拉维酸在急性中耳炎患者或急性支气管炎。头孢呋辛axetil至少是一样有效的青霉素V(青霉素V)治疗A组链球菌tonsillopharyngitis beta-haemolytic患者。许多研究已经评估的有效性头孢呋辛axetil静脉口服序贯治疗的口腔组件在住院患者下呼吸道感染。在每个研究患者接受肠外头孢呋辛大约2天之后,头孢呋辛axetil 5到10天。在比较研究中,头孢呋辛序贯疗法是有效的阿莫西林/克拉维酸序贯疗法和肠外头孢呋辛的完整课程,cefotiam或头孢哌酮。 Adults with urinary tract infections and skin infections were also effectively treated with cefuroxime axetil, as were adults and adolescents with early stage lyme disease. Cefuroxime axetil is associated with a low incidence of adverse events, with gastrointestinal disturbances being the most frequently observed. Thus, cefuroxime axetil is an effective and convenient treatment for a wide range of infections and may be considered a therapeutic option when empirical treatment of community-acquired infections is required. Moreover, given the promising results of several intravenous/oral sequential treatment studies, cefuroxime axetil may also become established as an oral component of sequential treatment regimens.

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药物

头孢呋辛