胶体铋subcitrate。回顾其药效学和药代动力学性质,及其治疗消化性溃疡疾病使用。

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瓦格斯塔夫AJ, Benfield P和尚JP

胶体铋subcitrate。回顾其药效学和药代动力学性质,及其治疗消化性溃疡疾病使用。

药。1988年8月,36 (2):132 - 57。

PubMed ID

3053124 (在PubMed

]

文摘

胶体铋subcitrate (CBS)具有至少等于功效与组胺H2-receptor拮抗剂药物治疗消化性溃疡疾病。然而,哥伦比亚广播公司(CBS)的优势比看到慢溃疡复发率与H2-antagonists初始治疗后。假定,这种效应可能是由于对弯曲杆菌螺杆菌CBS的抗菌性质,一种细菌中发现胃粘膜和胃十二指肠内化生消化性溃疡患者和与胃炎密切相关。然而,c .幽门在消化性疾病的病因学中的作用还远未清楚。CBS治疗溃疡的机制尚未完全阐明,但一些行为可能涉及。哥伦比亚广播公司和粘液形成glycoprotein-bismuth复杂的体外。这提供了一种盐酸扩散障碍,因此,提供了一个保护层溃疡火山口允许疗愈的病变发生。前列腺素E2与后续生产也刺激了CBS的分泌碱性黏液层。此外,哥伦比亚广播公司(CBS) c螺杆菌有直接的抑制作用。哥伦比亚广播公司管理导致低水平的铋吸收。 Most of the ingested bismuth is excreted as bismuth sulphide, causing blackening of the faeces, and the small amount absorbed is excreted in the urine. Bismuth intoxication (encephalopathy) has been reported with prolonged administration of bismuth salts, and there has been 1 report of similar intoxication in a patient receiving unusually high doses of CBS for a prolonged period. However, no such intoxication has been reported with CBS used at its recommended dosage in the acute treatment of peptic ulcer disease, and no other serious adverse effects have been associated with CBS. Tissue accumulation during prolonged therapy seems likely, and the safety of CBS during long term maintenance therapy has not been established. The lack of effect on gastric acid secretion is seen as an added advantage for CBS, since prolonged drug-induced hypochlorhydria has been postulated to have potentially detrimental effects. Thus, while the role of C. pylori in peptic ulceration requires further clarification, CBS would appear to have an important place in the treatment of peptic ulcer disease with the advantage of relatively slow relapse rates after initial healing and treatment discontinuation.

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药物

subcitrate铋钾