新陈代谢的抗凝血酶III(肝素辅因子)男:静脉血栓形成和肝素的影响。

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de Cock Collen D, Schetz J, F,霍尔默E,是M

新陈代谢的抗凝血酶III(肝素辅因子)男:静脉血栓形成和肝素的影响。

中国投资欧元。1977年2月,7 (1):27-35。

PubMed ID

65284年(在PubMed

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文摘

人类新陈代谢的抗凝血酶III(肝素辅因子)研究了在四个对照组,与周围闭塞的动脉疾病四个科目,在最近的六个患者静脉血栓形成在一个病人临床严重血友病a标记抗凝血酶III比活度高(5.75户/毫克),显示一个乐队SDS-polyacrylamide凝胶电泳。交联葡聚糖g - 100凝胶过滤标签材料筛选了一样在血浆抗凝血酶III活动。交叉免疫电泳混合新鲜血浆和标签的抗凝血酶III对一个特定的抗血清,透露一个沉淀素线辐射集中。的电泳淌度的变化后的血浆抗凝血酶III和标签材料增加肝素混合物或凝固后是相同的。蛋白质纯化抗凝血酶III表现为均匀的营业额实验。等离子体辐射数据被两个指数之和近似术语和抗凝血酶III的新陈代谢由两个隔间mammillary模型。在对照组结果如下:血浆抗凝血酶III浓度19.6 + / - 2.3毫克/ 100毫升;血管内分数0.45 + / - 0.05;部分分解率0.55 + / - 0.02每天浆池;等离子体辐射的半衰期2.83 + / - 0.26天。 Circulating large molecular weight degradation products of labelled antithrombin III could not be detected by Sephadex G-100 gel filtration. No significant differences in these parameters were found in the patients with peripheral arterial insufficiency. The turnover rate of antithrombin III was normal in the patient with haemophilia A. In three patients with venous thrombosis not treated with heparin, the turnover of labelled antithrombin III was in the normal range. In three patients with venous thrombosis, treated with heparin, the plasma radioactivity half-life was significantly shortened (2.13 +/- 0.08 days) and the fractional catabolic rate increased (0.75 +/- 0.05) of the plasma pool per day). In one of these patients, the labelled antithrombin III had been incubated with an equimolar amount of heparin prior to injection. In this patient the plasma radioactivity half-life was in the same range as in the other two patients (2.15 days).

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抗凝血酶III人类