证据的监管控制铁吸收的铁麦芽酚在大鼠的小肠。

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马Barrand Callingham英航

证据的监管控制铁吸收的铁麦芽酚在大鼠的小肠。

Br J杂志。1991年2月,102(2):408 - 14所示。doi: 10.1111 / j.1476-5381.1991.tb12187.x。

PubMed ID

2015422 (在PubMed

]

文摘

1。59铁吸收的小说铁化合物,铁麦芽酚,研究了大鼠连续两周每天两次进行预处理与非放射性铁麦芽酚口服剂量含有7毫克铁元素。组织积累59菲2 h后管理放射性铁麦芽酚到胃显著低于铁动物比saline-treated预处理控制。2。59铁吸收铁麦芽酚为孤立的碎片回肠和十二指肠是类似规模的控制动物但在iron-treated动物,十二指肠吸收明显低于回肠。3所示。59铁的吸收也调查了在麻醉大鼠肠道灌注与盐水(控制)或5毫米chenodeoxycholate呈现肠道更渗透。4所示。小肠渗透性的变化被估计量的监测[14 c]甘露醇和液体分泌参照non-absorbable吸收[3 h]菊粉在灌流液废水。5。 Despite the increased permeability of the intestines after bile salt treatment, there was little difference from control in the tissue accumulation of 59Fe from ferric maltol 2 h after intraduodenal administration. However 59Fe absorption from ferrous sulphate was significantly increased after bile salt treatment. 6. Gel filtration profiles of plasma made 5 and 60 min after intraduodenal administration of [59Fe]-ferric [3H]-maltol demonstrated that metal and ligand do not enter the circulation as the complex even when intestinal permeability is increased. 7. Uptake of 59Fe was investigated in isolated fragments of rat small intestine after saline or bile salt perfusion. Although 59Fe uptake from ferric maltol was somewhat greater in the bile salt-treated intestinal fragments, saturable kinetics were still observed. By contrast, "Fe uptake from ferrous sulphate: ascorbate was greatly enhanced by bile salt pretreatment and a very large diffusional component of uptake was evident. 8. It is concluded that iron uptake from ferric maltol may well be under endogenous regulatory control even in damaged intestines, so it is unlikely that this novel iron compound can bring about iron overload when administered orally.

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药物

铁麦芽酚