离解的铁麦芽酚复杂和随后的新陈代谢在老鼠的小肠吸收。

文章的细节

引用

复制到剪贴板

Barrand MA Callingham英航,驽马P,隐藏者RC

离解的铁麦芽酚复杂和随后的新陈代谢在老鼠的小肠吸收。

Br J杂志。1991年3月,102 (3):723 - 9。doi: 10.1111 / j.1476-5381.1991.tb12240.x。

PubMed ID

1364845 (在PubMed

]

文摘

1。的命运和性格(59 fe)铁[3 h]麦芽酚静脉注射后在麻醉大鼠进行调查。直接分离的三价铁麦芽酚发生在循环即使高剂量的铁麦芽酚(含有1毫克铁元素)。1分钟内血浆样品中撤回注入和凝胶过滤,59岁的菲筛选了与高分子量蛋白质而氚与低分子量物质。2。消除59 fe和氚的等离子体和他们的最终命运是非常不同的。59菲在等离子体的半衰期是70分钟左右,59铁主要出现在骨髓和肝脏。有一个初始快速退出氚的血浆半衰期约12分钟。然后通过高原或氚含量上升,包括麦芽酚代谢物进入血液循环。这些代谢物在尿液中恢复过来。3所示。 Entry of 59Fe and of tritium into the blood plasma after intraduodenal administration of [59Fe]-ferric [3H]-maltol was also very different. At low doses of ferric maltol (containing 100 micrograms elemental iron), the tritium appeared in the plasma in highest amounts within seconds and then decreased whilst there was a slow rise in 59Fe levels. At higher doses of ferric maltol (containing 7 mg elemental iron), levels of 59Fe in the plasma were highest at 5 min and then fell whereas tritium levels rose steadily. Mucosal processing of 59Fe prevented further entry of iron at high dose into the circulation. 4. Initial rates of uptake of [3H]-maltol into isolatcd intestinal fragments were measured over a range of concentrations and revealed that maltol alone could diffuse freely into the tissues whereas maltol complexed to iron showed saturable uptake kinetics similar to those seen with the iron itself. 5. After intestinal uptake, 59Fe and tritium were associated with different subcellular fractions, maltol itself being metabolized to the glucuronide conjugate within the intestinal mucosa. 6. It is concluded that dissociation of metal and ligand takes place before entry into the intestinal mucosa. Iron is then taken up on the endogenous carrier and processed in the normal way whilst maltol enters by diffusion, its rate of entry being limited by the degree of dissociation. It is subsequently metabolized by conjugation and eliminated rapidly from the body in the urine.

beplay体育安全吗DrugBank数据引用了这篇文章

药物

铁麦芽酚