活性氧和线粒体腺苷triphosphate-regulated钾离子通道调节helium-induced预处理对心肌梗死体内。

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由此PS, Krolikowski詹,普拉特PF Jr,垫片YH,恋情J, Warltier特区Weihrauch D

活性氧和线粒体腺苷triphosphate-regulated钾离子通道调节helium-induced预处理对心肌梗死体内。

J Cardiothorac Vasc Anesth。2008年8月,22 (4):554 - 9。doi: 10.1053 / j.jvca.2008.04.005。Epub 2008年6月17日。

PubMed ID

18662630 (在PubMed

]

文摘

目的:氦气生产预处理通过激活prosurvival激酶,但角色的活性氧(ROS)或线粒体腺苷triphosphate-regulated钾(K (ATP)通道在这个过程是未知的。作者测试假设活性氧和线粒体K (ATP)通道调解helium-induced预处理体内。设计:随机、前瞻性研究。设置:一所大学的研究实验室。参与者:雄性新西兰白兔。干预措施:兔子(n = 64)的测量仪器系统血液动力学和接受冠状动脉左前降枝30分钟(小伙子)闭塞和再灌注3小时。兔子在不同实验小组,每组(n = 7或8)被随机分配接受0.9%生理盐水(控制)或氦3周期的70% - 30%氧管理5分钟穿插5分钟的空气氧混合物在小伙子阻塞有或没有(ROS食腐动物防治南汽;150毫克/公斤)或n - mercaptoproprionyl甘氨酸(燃油效率;到了75毫克/公斤)或线粒体K (ATP)拮抗剂5-hydroxydecanoate(5 -羟色胺;5毫克/公斤)。 Statistical analysis of data was performed with analysis of variance for repeated measures followed by Bonferroni's modification of a Student t test. MEASUREMENTS AND MAIN RESULTS: The myocardial infarct size was determined by using triphenyltetrazolium chloride staining and presented as a percentage of the left ventricular area at risk. Helium significantly (p < 0.05) reduced infarct size (23 +/- 4% of the area at risk; mean +/- standard deviation) compared with control (46 +/- 3%). NAC, 2-MPG, and 5-HD did not affect irreversible ischemic injury when administered alone (49 +/- 5%, 45 +/- 6%, and 45 +/- 3%), but these drugs blocked reductions in infarct size produced by helium (45 +/- 4%, 45 +/- 2%, and 44 +/- 3%). CONCLUSIONS: The results suggest that ROS and mitochondrial K(ATP) channels mediate helium-induced preconditioning in vivo.

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