合成抗病毒药物Arbidol抑制致病性病毒在全球范围内流行。

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Pecheur EI, Borisevich V, Halfmann P, Morrey JD,志诚DF,普里查德M,沼泽CE, Kawaoka Y, Geisbert TW,波里亚克SJ

合成抗病毒药物Arbidol抑制致病性病毒在全球范围内流行。

J微生物学报。2016年1月6日,90 (6):3086 - 92。doi: 10.1128 / JVI.02077-15。

PubMed ID

26739045 (在PubMed

]

文摘

未标记的:Arbidol (ARB)是合成抗病毒最初开发以对抗流感病毒。ARB目前临床上用于几个国家但不是在北美。我们曾表明,ARB抑制体外丙型肝炎病毒(HCV)通过阻止丙肝病毒进入和复制。在这份报告中,我们扩展的列表的病毒抑制ARB和证明ARB抑制体外哺乳动物细胞的感染埃博拉病毒(EBOV) Tacaribe沙粒病毒,和人类疱疹病毒8 (HHV-8)。我们还证实抑制乙型肝炎病毒和脊髓灰质炎病毒ARB。ARB抑制EBOV扎伊尔Kikwit之前或同时添加时感染病毒感染和不添加EBOV感染后24 h时有效。实验与重组水泡性口炎病毒(VSV)表达EBOV扎伊尔糖蛋白表明感染抑制ARB的早期阶段,最有可能在病毒进入宿主细胞的水平。ARB抑制HHV-8 cidofovir复制类似的程度。数据扩大抗病毒疗效的ARB的光谱包括全球流行病毒导致重大的发病率和死亡率。重要性:有许多病毒在全球范围内普遍没有许可的疫苗和抗病毒药物。 Some of these viruses, such as Ebola virus or members of the arenavirus family, rapidly cause severe hemorrhagic diseases that can be fatal. Other viruses, such as hepatitis B virus or human herpesvirus 8 (HHV-8), establish persistent infections that cause chronic illnesses, including cancer. Thus, finding an affordable, effective, and safe drug that blocks many viruses remains an unmet medical need. The antiviral drug arbidol (ARB), already in clinical use in several countries as an anti-influenza treatment, has been previously shown to suppress the growth of many viruses. In this report, we expand the list of viruses that are blocked by ARB in a laboratory setting to include Ebola virus, Tacaribe arenavirus, and HHV-8, and we propose ARB as a broad-spectrum antiviral drug that may be useful against hemorrhagic viruses.

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药物

Umifenovir