治疗深膝盖软骨缺损自体软骨细胞移植。
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Brittberg M,林达尔,尼尔森,欧胜C,法甲O,彼得森L
治疗深膝盖软骨缺损自体软骨细胞移植。
郑传经地中海J。1994年10月6日,331 (14):889 - 95。
- PubMed ID
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8078550 (在PubMed]
- 文摘
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背景:关节软骨全层缺损的膝盖有一个贫穷的修复能力。他们可能会发展为骨关节炎,需要全膝关节置换。我们进行了自体软骨细胞移植在23人深膝盖软骨缺陷。方法:患者年龄从14岁到48年,全层软骨缺损的大小不等,从1.6到6.5平方厘米。健康的软骨细胞从一位获得区域分离、培养受伤的膝盖关节镜检查期间在实验室14 - 21天。培养的软骨细胞被注入缺陷的面积。缺陷是缝合骨膜皮瓣覆盖从近端胫骨内侧。根据明确的标准评价包括临床检查和关节镜检查和活检的移植。结果:患者随访16至66个月(意思是,39)。最初,移植了膝盖锁定,在所有的病人减少疼痛和肿胀。 After three months, arthroscopy showed that the transplants were level with the surrounding tissue and spongy when probed, with visible borders. A second arthroscopic examination showed that in many instances the transplants had the same macroscopic appearance as they had earlier but were firmer when probed and similar in appearance to the surrounding cartilage. Two years after transplantation, 14 of the 16 patients with femoral condylar transplants had good-to-excellent results. Two patients required a second operation because of severe central wear in the transplants, with locking and pain. A mean of 36 months after transplantation, the results were excellent or good in two of the seven patients with patellar transplants, fair in three, and poor in two; two patients required a second operation because of severe chondromalacia. Biopsies showed that 11 of the 15 femoral transplants and 1 of the 7 patellar transplants had the appearance of hyaline cartilage. CONCLUSION: Cultured autologous chondrocytes can be used to repair deep cartilage defects in the femorotibial articular surface of the knee joint.
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