自体软骨细胞移植与膝盖微裂缝。一个随机试验。

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Knutsen G, Engebretsen L, Ludvigsen TC, Drogset乔Grontvedt T, Solheim E T链,罗伯茨年代,Isaksen V,约翰森O

自体软骨细胞移植与膝盖微裂缝。一个随机试验。

中华骨科杂志。2004年3月,86,(3):455 - 64。

PubMed ID

14996869 (在PubMed

]

文摘

背景:新方法已经被使用,有前景的结果,治疗全层软骨缺损。本研究的目的是比较自体软骨细胞移植与微裂缝随机试验。我们不知道任何先前的随机研究比较这些方法。方法:八十例无骨关节炎一般有一个症状在一个稳定的股骨髁膝关节软骨缺陷用自体软骨细胞移植治疗或微裂缝在每组(40)。我们使用国际软骨修复社会、Lysholm短Form-36 (SF-36)和Tegner形式来收集数据。一个独立的观察者进行12和24个月的随访检查。术后两年,关节镜检查和活检组织学评价。组织学评价是由一个病理学家和临床科学家,两人对每个病人的治疗也不清楚。结果:一般来说,两治疗组之间存在微小的差异。在两年,两组有显著的临床改善。 According to the SF-36 physical component score at two years postoperatively, the improvement in the microfracture group was significantly better than that in the autologous chondrocyte implantation group (p = 0.004). Younger and more active patients did better in both groups. There were two failures in the autologous chondrocyte implantation group and one in the microfracture group. No serious complications were reported. Biopsy specimens were obtained from 84% of the patients, and histological evaluation of repair tissues showed no significant differences between the two groups. We did not find any association between the histological quality of the tissue and the clinical outcome according to the scores on the Lysholm or SF-36 form or the visual analog scale. CONCLUSIONS: Both methods had acceptable short-term clinical results. There was no significant difference in macroscopic or histological results between the two treatment groups and no association between the histological findings and the clinical outcome at the two-year time-point. LEVEL OF EVIDENCE: Therapeutic study, Level I-1a (randomized controlled trial [significant difference]). See Instructions to Authors for a complete description of levels of evidence.

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自体软骨细胞培养