神经肌肉doxacurium氯isoflurane-anesthetized狗的影响。

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马丁内斯EA,里奇AA, Hartsfield SM, Mealey KL

神经肌肉doxacurium氯isoflurane-anesthetized狗的影响。

兽医Surg. 1998 May-Jun; 27 (3): 279 - 83。

PubMed ID

9605239 (在PubMed

]

文摘

目的:确定神经肌肉doxacurium氯的影响和建立一个药物的剂量反应曲线isoflurane-anesthetized狗。设计:随机对照试验。动物:六个健康,成年的混血狗(五女一男)24.8 + / - 2.8公斤。方法:麻醉诱导与异氟烷氧和维护与end-tidal 1.9%到2.3%异氟烷的浓度。PaCO2保持35 - 45毫米汞柱与机械通气。Mechanomyography被用来量化的诱发抽动响应超大的后爪train-of-four肤浅的腓神经的刺激。基线值记录后,狗收到三种剂量的doxacurium (2.0, 3.5, 4.5 microg /公斤体重)或安慰剂生理盐水静脉注射以随机的顺序。所有的狗都收到之间的所有治疗至少有7天的研究。药品监督管理局后,最大程度的第一次抽搐抑郁症与基线相比(T1%)被记录。剂量反应关系doxacurium日志dose-probit格式的绘制和分析了线性回归确定有效剂量doxacurium (ED50和ED90)值。 RESULTS: The median log dose-probit response curve showed good data correlation (r = .999) with estimates of the ED50 (2.1 microg/kg) and ED90 (3.5 microg/kg) for doxacurium in isoflurane-anesthetized dogs. Mean +/- SD values for T1% (first twitch tension compared with baseline) at maximal depression after drug administration, onset (time from drug administration to maximal depression of T1%), duration (time from maximal depression of T1% to 25% recovery of T1%), and recovery (time from 25% to 75% recovery of T1%) times were 92% +/- 4%, 40 +/- 5 minutes, 108 +/- 31 minutes, and 42 +/- 11 minutes for dogs treated with 3.5 microg/kg of doxacurium and 94% +/- 7%, 41 +/- 8 minutes, 111 +/- 33 minutes, and 37 +/- 10 minutes for dogs treated with 4.5 microg/kg of doxacurium. CONCLUSION AND CLINICAL RELEVANCE: We conclude that doxacurium is a long-acting neuromuscular blocking agent with a slow onset of action. Doxacurium can be used to provide muscle relaxation for long surgical procedures in isoflurane-anesthetized dogs. Interpatient variability, particularly of duration of drug action, may exist in the neuromuscular response to the administration of doxacurium in dogs.

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药物

Doxacurium