高浓度的自由分子的存在人类唾液酸。

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经营着Y,东M, Ishii Y,佐H, Tanigawa M,经营着K,野口K, Urade M

高浓度的自由分子的存在人类唾液酸。

生命科学。2006年3月6日,78 (15):1677 - 81。Epub 2006 2月9。

PubMed ID

16480744 (在PubMed

]

文摘

免费的中性分子酸中曾发现了人类的等离子体,通常占不到2%的总游离氨基酸浓度(分子酸比值)[经营,Y。Masui, R。Akino, T。1992一个。存在自由D-serine D-alanine D-proline人血浆。Experientia 48岁,986 - 988。经营,Y。山本,K。小村子里,T。1992 b。D -和l -氨基酸测定的高效液相色谱在小鼠肾脏。色谱法575年学报,147 - 152。经营,Y。山本,K。小村子里,T。Konno, R。Yasumura, Y。Akino, T。1992 c。 The presence of free D-alanine, D-proline and D-serine in mice. Biochimca et Biiophysica Acta 1115, 208-211]. In the present study to search for the source of free D-amino acids, D- and L-enantiomers of the major non-essential amino acids, i.e., the free form of serine, alanine, proline, aspartate and glutamate were analyzed by HPLC in human saliva, submandibular glands and oral epithelial cells. The D-enantiomer ratios to total of free alanine or proline were 35% and 20%, respectively, in saliva. The ratios of the other D-amino acids were less than 11%. The effect of ingested food and oral bacteria on the saliva amino acid levels was suggested to be insignificant. D-Alanine and d-aspartate were also detected in the submandibular gland in ratios up to 5%, and D-alanine and d-proline were found in oral epithelial cells in ratios of 18% and 5%, respectively. The submandibular gland and oral epithelial cells are suggested to be possible sources of the saliva D-alanine and D-aspartate.

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药物

D-Proline