与液氮冷冻疗法与局部水杨酸申请在初级保健皮肤疣:随机对照试验。

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Bruggink SC, Gussekloo J,伯杰,Zaaijer K, Assendelft WJ, de Waal MW, Bavinck约,ko BW, Eekhof农协

与液氮冷冻疗法与局部水杨酸申请在初级保健皮肤疣:随机对照试验。

协会。2010年10月19日,182 (15):1624 - 30。doi: 10.1503 / cmaj.092194。Epub 2010年9月13日。

PubMed ID

20837684 (在PubMed

]

文摘

背景:冷冻疗法被广泛用于治疗皮肤疣在初级保健。然而,证据支持水杨酸的应用程序。我们比较这些疗法的有效性以及观望的态度。方法:连续新皮肤疣患者招募了30初级护理实践5月1日之间在荷兰,2006年和2007年1月26日。我们随机分配资格病人三组:每两周与液氮冷冻疗法、自我应用水杨酸每日或观望的态度。主要结果是参与者的比例在13周疣都治好了。分析在意向性治疗基础上。二次结果包括治疗依从性,副作用和治疗满意度。研究护士家访期间评估结果4、13和26周。结果:250名参与者的4岁(79年),240年被包含在分析13周(追踪损失4%)。 Cure rates were 39% (95% confidence interval [CI] 29%-51%) in the cryotherapy group, 24% (95% CI 16%-35%) in the salicylic acid group and 16% (95% CI 9.5%-25%) in the wait-and-see group. Differences in effectiveness were most pronounced among participants with common warts (n = 116): cure rates were 49% (95% CI 34%-64%) in the cryotherapy group, 15% (95% CI 7%-30%) in the salicylic acid group and 8% (95% CI 3%-21%) in the wait-and-see group. Cure rates among the participants with plantar warts (n = 124) did not differ significantly between treatment groups. INTERPRETATION: For common warts, cryotherapy was the most effective therapy in primary care. For plantar warts, we found no clinically relevant difference in effectiveness between cryotherapy, topical application of salicylic acid or a wait-and-see approach after 13 weeks. (ClinicalTrial.gov registration no. ISRCTN42730629).

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