机理和影响葡萄糖的吸收在女性和男性之间的口服葡萄糖耐量试验。
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Anderwald C, Gastaldelli发信息给鲍思高堂另一个,克雷布斯M, Promintzer-Schifferl M, Kautzky-Willer,施M, DeFronzo RA, Pacini G,女孩毫克
机理和影响葡萄糖的吸收在女性和男性之间的口服葡萄糖耐量试验。
中国性金属底座。2011年2月,96 (2):515 - 24。doi: 10.1210 / jc.2010 - 1398。Epub 2010年12月8日。
- PubMed ID
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21147888 (在PubMed]
- 文摘
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背景:一些流行病学研究显示性别差异在口服葡萄糖耐量试验(OGTT),如更高的葡萄糖耐受不良患病率(即增加糖的OGTT)女性,不解释。因此,我们旨在分析OGTT葡萄糖代谢与性有关的区别,包括肠道吸收,在健康的人类。方法:女性(n = 48)和男性(n = 26)与年龄(女性,45 + / - 1年;男性,44 + / - 2年)和身体质量指数(两者,25 + / - 1公斤/米(2)),但不同的高度(女性,166 + / - 1厘米;男性,180 + / - 2厘米;P < 0.000001),所有正常葡萄糖宽容,经常取样测试,3 - h (75 - g) ogtt,经历了血糖[40亩/分钟。米(2)))isoglycemic夹测试同步量测的内源性葡萄糖(d - H[6 6 -(2)(2)]葡萄糖)生产(出路。出路和葡萄糖消失在OGTT计算从对数关系夹测试胰岛素浓度。经过double-tracer可靠的模型验证技术(r = 0.732;P < 0.007),我们计算和建模肠道葡萄糖吸收(ABS)。 RESULTS: Females showed lower (P < 0.05) fasting EGP [1.4 +/- 0.1 mg/(kg . min)] than males [1.7 +/- 0.1 mg/(kg . min)] but comparable whole-body insulin sensitivity in clamp tests [females, 8.1 +/- 0.4 mg/(kg . min); males, 8.3 +/- 0.6 mg/(kg . min)]. Plasma glucose OGTT concentrations were higher (P < 0.04) from 30-40 min in males but from 120-180 min in females. Glucose absorption rates were 21-46% increased in the initial 40 min in males but in females by 27-40% in the third hour (P < 0.05). Gut glucose half-life was markedly higher in females (79 +/- 2 min) than in males (65 +/- 3 min, P < 0.0001) and negatively related to body height (r = -0.481; P < 0.0001). CONCLUSIONS: This study in healthy, glucose-tolerant humans shows for the first time different ABS rates during OGTT in women and men and a negative relationship between body height and gut glucose half-life. Prolonged ABS in females might therefore contribute to higher plasma glucose concentrations at the end of OGTT.
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