随机临床试验仅静脉豆油和豆油加鱼油乳液后胃肠道癌症手术。

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江泽民ZM评选,Wilmore DW,王XR,魏JM,张ZT型,顾ZY,王年代,韩寒SM,江H, Yu K

随机临床试验仅静脉豆油和豆油加鱼油乳液后胃肠道癌症手术。

Br J Surg. 2010年6月,97 (6):804 - 9。doi: 10.1002 / bjs.6999。

PubMed ID

20473991 (在PubMed

]

文摘

背景:特定immunonutrients可以降低术后并发症的发生率,缩短恢复时间。这个随机试验的临床疗效评估结果鱼油乳液,胃肠道癌症手术后免疫功能。方法:总共有206胃肠道或结肠癌患者被随机分配接受等热量的单独和isonitrogenous静脉注入大豆油(每天每公斤体重1.2克;对照组,103)或分析大豆加鱼油乳液(分别为1.0和0.2克/公斤/天;治疗组,100分析)在20 - 24 h后7天内每日手术。结果:两组基线数据可比性。有更少的感染性并发症(四对12 8天;P = 0.066),全身炎症反应综合征(SIRS)明显不常见(4和13;P = 0.039),住院时间明显缩短(意思是(他)15(5)和(8)17天;在治疗组P = 0.041)。 Total postoperative medical costs were comparable in the two groups (mean(s.d.) US $ 1269(254) and 1302(324) in treatment and control groups respectively; P = 0.424). The median (interquartile range) difference in CD4/CD8 between days 1 and 8 after surgery was + 0.30 (0.06 to 0.79) in patients receiving fish oil and + 0.20 (-0.19 to 0.55) in controls (P = 0.021). No severe adverse events occurred in either group. CONCLUSION: Fish oil emulsion-supplemented parenteral nutrition significantly reduced SIRS and length of hospital stay. These clinical benefits may be related to normalization of cellular immune functions and modulation of the inflammatory response.

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药物

大豆油